Taylor S M, Jones P A
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Substantial evidence now points to DNA methylation playing a primary role in locking genes in the "off' condition. Specific hypomethylation events may be necessary but not sufficient for gene expression. 5-azacytidine is a useful drug to perturb DNA methylation patterns and determine the effects of these perturbations on gene expression.
大量证据表明，DNA甲基化在将基因锁定在“关闭”状态中起主要作用。特定的低甲基化事件可能是基因表达所必需的，但并不充分。5-氮杂胞苷是一种用于扰乱DNA甲基化模式并确定这些干扰对基因表达影响的有用药物。
