Tang L, Fang Z F, Zhou S H
Department of Cardiology, The Second Xiangya Hospital of Central South University, Middle Ren-Min road No. 139, 410011, Changsha, Hunan, China.
Herz. 2015 Apr;40(2):314-7. doi: 10.1007/s00059-013-3994-9. Epub 2013 Oct 25.
Paradoxical embolism (PDE) is an uncommon but clinically important entity. In clinical practice, PDE involving multiple organs is a rarely reported occurrence. Herein, we present a case of acute pulmonary embolism complicated by PDE through an atrial septal defect (ASD) causing a series of embolic events. Subsequent laboratory screening confirmed the patient to be a heterozygous carrier of the factor V Leiden mutation that increases the risk for deep venous thrombosis (DVT). The patient was treated with warfarin indefinitely and underwent transcatheter ASD closure and implantation of an inferior vena cava filter.
反常栓塞（PDE）是一种罕见但具有临床重要性的病症。在临床实践中，累及多个器官的PDE鲜有报道。在此，我们报告一例急性肺栓塞合并通过房间隔缺损（ASD）发生的PDE病例，该病例引发了一系列栓塞事件。随后的实验室筛查证实该患者为因子V莱顿突变的杂合子携带者，这增加了深静脉血栓形成（DVT）的风险。该患者接受了长期华法林治疗，并接受了经导管ASD封堵术及下腔静脉滤器植入术。
