C-苯并[a]芘及其7,8-二氢二醇和7,8-二酮的合成被认为是致癌代谢产物。
Synthesis of C-Benzo[]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic Metabolites.
作者信息
Ran Chongzhao, Xu Daiwang, Dai Qing, Penning Trevor M, Blair Ian A, Harvey Ronald G
机构信息
Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637.
出版信息
Tetrahedron Lett. 2008 Jul 21;49(29-30):4531-4533. doi: 10.1016/j.tetlet.2008.05.033.
Abstract
Synthesis of the -labelled analogues of the carcinogenic polycyclic aromatic hydrocarbon benzo[]pyrene and its active metabolites are described. The method entails Pd-catalyzed Suzuki-Miyaura coupling of a naphthalene boronic acid with 2-bromobenzene-1,3-dialdehyde followed by Wittig reaction of the product with CH=PPh.
摘要
描述了致癌多环芳烃苯并[]芘及其活性代谢物的 - 标记类似物的合成。该方法包括萘硼酸与2 - 溴苯 - 1,3 - 二醛的钯催化铃木 - 宫浦偶联反应，然后产物与CH = PPh进行维蒂希反应。
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