Talukdar Ranadeep
Molecular Synthesis and Drug Discovery Laboratory, Centre of Biomedical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow-226014 India
RSC Adv. 2020 Aug 25;10(52):31363-31376. doi: 10.1039/d0ra05111j. eCollection 2020 Aug 21.
Alkoxybenzenes and alkoxynaphthalenes, as nucleophiles, have drawn great attention from organic chemists over the decades. Due to their high ring strain, those particular classes of molecules are often used in synthesis by utilizing their properties to undergo facile Friedel-Crafts alkylations. Different isomeric and low or densely substituted alkoxybenzenes are used for synthesis according to the structure of the target molecule. Isomeric methoxybenzenes, are the most commonly used molecule in this regard. This review aims to comprehensively cover the instances of different alkoxy-benzenes/naphthalenes used as nucleophiles for ring opening.
几十年来,作为亲核试剂的烷氧基苯和烷氧基萘一直备受有机化学家的关注。由于其高环张力,这些特定类型的分子常被用于合成,利用它们易于进行傅克烷基化反应的性质。根据目标分子的结构,使用不同的异构体以及低取代或高取代的烷氧基苯进行合成。在这方面,异构甲氧基苯是最常用的分子。本综述旨在全面涵盖不同烷氧基苯/萘用作亲核试剂进行开环反应的实例。