Department of Anesthesiology and Pain Medicine, School of Medicine, Wonkwang University, Iksan, Korea.
Korean J Pain. 2013 Oct;26(4):361-7. doi: 10.3344/kjp.2013.26.4.361. Epub 2013 Oct 2.
Nefopam is a centrally acting analgesic that is used to control pain. The aim of this study was to find an appropriate dose of nefopam that demonstrates an analgesic effect when administered in continuous infusion with fentanyl at the end of laparoscopic cholecystectomy.
Ninety patients scheduled for laparoscopic cholecystectomy were randomly assigned to receive analgesia with fentanyl alone (50 µg, Group 1, n = 30), or with fentanyl in combination with nefopam 20 mg (Group 2, n = 30) or in combination with nefopam 40 mg (Group 3, n = 30) at the end of surgery. Pain and side effects were evaluated at 10 minutes, 30 minutes, 1 hour, 2 hours, 6 hours, and 12 hours after arrival in the post-anesthesia care unit (PACU).
Pain was statistically significantly lower in Groups 2 and 3 than in Group 1 at 10 minutes, 2 hours, and 6 hours after arrival in the PACU. Nausea was statistically significantly lower in Group 2 than in Groups 1 and 3 at 10 minutes after arrival in the PACU. Shivering was statistically significantly lower in Groups 2 and 3 than in Group 1 at 10 minutes after arrival in the PACU.
Nefopam is a drug that can be safely used as an analgesic after surgery, and its side effects can be reduced when fentanyl 50 µg is injected with nefopam 20 mg.
奈福泮是一种中枢作用的镇痛药，用于控制疼痛。本研究的目的是在腹腔镜胆囊切除术后使用芬太尼持续输注时，寻找奈福泮的合适剂量，以发挥镇痛作用。
90 例行腹腔镜胆囊切除术的患者被随机分为三组，分别接受芬太尼单独镇痛（50μg，组 1，n=30）、芬太尼联合奈福泮 20mg（组 2，n=30）或芬太尼联合奈福泮 40mg（组 3，n=30）。术后在麻醉后恢复室（PACU）评估疼痛和不良反应，时间点为 10 分钟、30 分钟、1 小时、2 小时、6 小时和 12 小时。
与组 1 相比，组 2 和组 3 在 PACU 到达后 10 分钟、2 小时和 6 小时时疼痛明显减轻。组 2 在 PACU 到达后 10 分钟时恶心发生率明显低于组 1 和组 3。组 2 和组 3 在 PACU 到达后 10 分钟时寒战发生率明显低于组 1。
奈福泮是一种安全的术后镇痛药，当芬太尼 50μg 与奈福泮 20mg 联合使用时，其不良反应可减少。
