Bloem A C, Heijnen C J, Bast B J, Ballieux R E
J Immunol. 1985 Dec;135(6):4261-5.
Nylon wool-purified T cells (Tn) of two patients with chronic lymphocytic leukemia of the B cell type were phenotyped and tested in various assays for antigen-specific T helper (Th), T suppressor effector (Tse), T suppressor precursor (Tsp), and T suppressor inducer (Tsi) function. Antigen-specific Th as well as Tsi activity could be effectively generated. Although phenotypically CD8+ T cells, carrying the receptor for the Fc part of IgG, were present in mononuclear blood cells and Tn fractions, no antigen-specific Tse cell activity could be induced. In addition, Tsp cells were found to be functionally absent. These findings are discussed in relation to a tumor-induced limited heterogeneity within the T suppressor (Ts) cell compartment.
对两名B细胞型慢性淋巴细胞白血病患者的尼龙毛纯化T细胞（Tn）进行了表型分析，并在各种试验中检测了抗原特异性T辅助细胞（Th）、T抑制效应细胞（Tse）、T抑制前体细胞（Tsp）和T抑制诱导细胞（Tsi）的功能。可以有效产生抗原特异性Th以及Tsi活性。尽管在单核血细胞和Tn组分中存在表型上为CD8 + T细胞，其携带IgG Fc部分的受体，但未诱导出抗原特异性Tse细胞活性。此外，发现Tsp细胞在功能上不存在。结合肿瘤诱导的T抑制（Ts）细胞区室内有限的异质性对这些发现进行了讨论。
