Zhao Lei, Hao Sha, Yuan Wei-Ping, Cheng Tao
State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Oct;21(5):1345-50. doi: 10.7534/j.issn.1009-2137.2013.05.052.
NKT cells (nature killer T cells), as a regulatory cellular compartment in the immune system, express cell surface markers of T cells and NK cells. It secretes a variety of cytokines that stimulate specific antigens. Through regulating the balance of Th1/Th2, the NKT cells play an important role in prevention and treatment of graft-versus-host disease (GVHD). Its antitumor and anti-infectious effects serve as a basis of its application in allogeneic hematopoietic stem cell transplantation. A better understanding of the biological and immunological features of NKT cell, as well as its specific immune regulatory mechanisms, will further justify the rationales of using NKT cells in the management of GVHD for patients. In this review, the biologic properties, classification, differentiation and development, immune activation of NKT cells as well as the NKT cells and GVHD including the related mechanisms of prevention and treatment of GVHD with NKT cells, NKT cells and tumors, NKT cells and infection, and NKT cells and clinical GVHD are summarized.
自然杀伤T细胞（NKT细胞）作为免疫系统中的一个调节性细胞亚群，表达T细胞和NK细胞的细胞表面标志物。它分泌多种刺激特异性抗原的细胞因子。通过调节Th1/Th2平衡，NKT细胞在移植物抗宿主病（GVHD）的防治中发挥重要作用。其抗肿瘤和抗感染作用是其在异基因造血干细胞移植中应用的基础。更好地了解NKT细胞的生物学和免疫学特性及其特异性免疫调节机制，将进一步证明在患者GVHD管理中使用NKT细胞的合理性。在本综述中，总结了NKT细胞的生物学特性、分类、分化与发育、免疫激活以及NKT细胞与GVHD，包括NKT细胞防治GVHD的相关机制、NKT细胞与肿瘤、NKT细胞与感染以及NKT细胞与临床GVHD。
