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腹腔镜射频消融治疗小肾肿瘤:长期肿瘤学结果。

Laparoscopic radiofrequency ablation of small renal tumors: long-term oncologic outcomes.

机构信息

Department of Urology, UT Southwestern Medical Center , Dallas, Texas.

出版信息

J Endourol. 2014 Mar;28(3):330-4. doi: 10.1089/end.2013.0542. Epub 2013 Dec 28.

Abstract

INTRODUCTION

Unlike percutaneous radiofrequency ablation (RFA) of small renal tumors, there are limited data assessing the long-term efficacy of laparoscopic RFA. Although the ablation cannot be visualized as reliably as with cryoablation, laparoscopic RFA allows for improved mobilization and placement of probes under direct vision. We reviewed our experience with laparoscopic RFA to assess long-term oncologic outcomes.

METHODS

We performed a retrospective study of all patients who had undergone laparoscopic RFA for pT1a renal tumors from April 2000 to April 2010. Demographic, clinical, and radiologic data were assessed to determine indications and evidence for recurrence of disease. Radiologic recurrence was defined as any new enhancement (>10 HU) after absence of enhancement on initial negative 6-week computed tomography.

RESULTS

Data were available for 79 patients who had 111 small renal masses treated over the 10-year period. The median tumor diameter was 2.2 cm and intraoperative biopsy identified renal cell carcinoma in 77%. The median follow-up was 59 months with an estimated 5-year recurrence-free survival of 93.3%. The overall rate of complications was 8.8% with a 3.8% rate of major complications.

CONCLUSIONS

Long-term experience with laparoscopic RFA demonstrates that it is a safe and effective option for the treatment of small renal tumors. Five-year oncologic outcomes appear to be comparable to extirpation.

摘要

简介

与小肾肿瘤的经皮射频消融(RFA)不同,评估腹腔镜 RFA 长期疗效的数据有限。虽然消融不能像冷冻消融那样可靠地可视化,但腹腔镜 RFA 允许在直接视野下更好地移动和放置探头。我们回顾了我们使用腹腔镜 RFA 的经验,以评估长期的肿瘤学结果。

方法

我们对 2000 年 4 月至 2010 年 4 月期间接受腹腔镜 RFA 治疗 pT1a 肾肿瘤的所有患者进行了回顾性研究。评估了人口统计学、临床和影像学数据,以确定疾病复发的指征和证据。影像学复发定义为初始阴性 6 周 CT 后出现任何新的增强(>10 HU)。

结果

在 10 年期间,有 79 名患者的 111 个小肾肿块的数据可用。肿瘤直径中位数为 2.2 cm,术中活检确定为肾细胞癌 77%。中位随访时间为 59 个月,估计 5 年无复发生存率为 93.3%。总的并发症发生率为 8.8%,严重并发症发生率为 3.8%。

结论

腹腔镜 RFA 的长期经验表明,它是治疗小肾肿瘤的一种安全有效的选择。5 年的肿瘤学结果似乎与切除术相当。

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