用于测定血清中唾液酸转移酶活性的载体结合受体的制备与应用。
The preparation and use of a carrier-bound acceptor for the determination of sialyl transferase activity in serum.
作者信息
Ganzinger U, Unger F M
出版信息
J Clin Chem Clin Biochem. 1985 Oct;23(10):691-5. doi: 10.1515/cclm.1985.23.10.691.
PMID:2415667
Abstract
Agarose-bound asialofetuin functions as an insoluble sialyl group acceptor in a simplified assay for sialyl transferase (CMP-neuraminate: D-galactosyl-glycoprotein N-acetylneuraminyl transferase; EC 2.4.99.1) in serum. Since sialyl transferase levels in serum are elevated in a large number of malignant conditions, the simplified assay is of use for clinical monitoring in tumour therapeutic programmes.
摘要
在血清唾液酸转移酶（CMP-唾液酸：D-半乳糖基-糖蛋白N-乙酰神经氨酸转移酶；EC 2.4.99.1）的简易检测中，琼脂糖结合的去唾液酸胎球蛋白可作为不溶性唾液酸基团受体。由于在大量恶性疾病中血清唾液酸转移酶水平会升高，因此该简易检测方法可用于肿瘤治疗方案中的临床监测。
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