Arrabal-Polo M A, Vera-Arroyo B, Lahoz-García C, Valderrama-Illana P, Cámara-Ortega M, Arrabal-Martín M, Zuluaga-Gomez A, Lopez-Carmona Pintado F
UGC Urología, Hospital Universitario San Cecilio, Granada, España.
UGC Angiología y Cirugía Vascular, Hospital Universitario San Cecilio, Granada, España.
Actas Urol Esp. 2014 Apr;38(3):179-83. doi: 10.1016/j.acuro.2013.09.005. Epub 2013 Oct 21.
Different studies have shown the relationship between erectile dysfunction, metabolic syndrome and cardiovascular disease. The objective of this study was to evaluate the presence of arteriopathy performing carotid ultrasound in patients with and without erectile dysfunction.
We conducted a case-control study with 44 patients consulting for erectile dysfunction and 20 controls. All subjects completed the IIEF-5 test and we studied the criteria for metabolic syndrome, and a carotid ultrasound to study the intima-media thickness and the presence of atherosclerotic plaques was performed.
Mean intima-media thickness was .71mm±.21 for the right and of .71±.17 for the left carotid in patients with erectile dysfunction. In the control group, the means were .54±0.11 and 0.59±0.15mm respectively, statistically significant differences (P=.02 and P=.05 respectively). No plaque was found in any control, but in 25% of both carotid arteries of patients with erectile dysfunction (P=.01). As metabolic syndrome, according to the American Heart Association, were diagnosed 52.8% of patients with erectile dysfunction, and 16.7% of controls, and according to the International Diabetes Federation, 52.3% of patients with erectile dysfunction and 25% of controls met diagnostic criteria. In both cases there were significant differences (P<.01 and P=.02 respectively). We found a positive linear correlation between waist circumference and the intima-media thickness in both carotid (P<.05).
Patients with erectile dysfunction may be at increased risk of cardiovascular disease, as determined by the presence of arterial disease in the carotid arteries, which indicates that we should made a more thorough and comprehensive study of patients with erectile dysfunction.
不同研究已表明勃起功能障碍、代谢综合征与心血管疾病之间的关系。本研究的目的是通过对有和没有勃起功能障碍的患者进行颈动脉超声检查来评估动脉病变的存在情况。
我们进行了一项病例对照研究，其中有44名因勃起功能障碍前来咨询的患者和20名对照者。所有受试者均完成了国际勃起功能指数-5测试，我们研究了代谢综合征的标准，并进行了颈动脉超声检查以研究内膜中层厚度和动脉粥样硬化斑块的存在情况。
勃起功能障碍患者右侧颈动脉内膜中层平均厚度为0.71mm±0.21，左侧为0.71±0.17mm。在对照组中，平均值分别为0.54±0.11和0.59±0.15mm，差异有统计学意义（分别为P = 0.02和P = 0.05）。对照组中未发现斑块，但勃起功能障碍患者双侧颈动脉中有25%发现斑块（P = 0.01）。根据美国心脏协会的标准，52.8%的勃起功能障碍患者被诊断为代谢综合征，对照组为16.7%；根据国际糖尿病联盟的标准，52.3%的勃起功能障碍患者和25%的对照者符合诊断标准。在这两种情况下均存在显著差异（分别为P<0.01和P = 0.02）。我们发现腰围与双侧颈动脉内膜中层厚度之间存在正线性相关性（P<0.05）。
勃起功能障碍患者可能因颈动脉存在动脉疾病而有患心血管疾病的风险增加，这表明我们应对勃起功能障碍患者进行更全面深入的研究。
