Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Department of Radiodiagnosis and Intervention, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Andrologia. 2021 Sep;53(8):e14127. doi: 10.1111/and.14127. Epub 2021 May 29.
Obesity is a risk factor for erectile dysfunction and atherosclerosis. Lipocalin-2 is an adipocytokine with proinflammatory properties involved in several disorders with metabolic alterations. Our aim was to study the relation of serum lipocalin-2 and carotid artery intima-media thickness (CIMT) to obesity in erectile dysfunction. Serum lipocalin-2 and CIMT were measured in 25 obese and 25 nonobese eugonadal patients over forty with venogenic erectile dysfunction and 25 healthy controls. Their relation to different patient- and disease-related parameters was studied. Results revealed lipocalin-2 to be significantly higher in obese compared with nonobese patients and with controls, and in nonobese patients compared with controls. CIMT was lower in controls compared with both obese and nonobese patients. In obese and nonobese patients, lipocalin-2 was positively correlated with disease duration, body mass index, waist circumference and end-diastolic velocity. Lipocalin-2 was negatively correlated with the short form of the international index of erectile function scores in both groups. In conclusion, the elevated lipocalin-2 in obese and to a lesser extent in nonobese patients and its association with disease severity points to its potential value as a diagnostic marker and a possible therapeutic target that could ameliorate the metabolic derangement associated with erectile dysfunction.
肥胖是勃起功能障碍和动脉粥样硬化的一个危险因素。脂联素-2 是一种具有促炎特性的脂肪细胞因子，与几种代谢紊乱的疾病有关。我们的目的是研究血清脂联素-2 与颈动脉内膜中层厚度（CIMT）与勃起功能障碍肥胖之间的关系。在 25 名肥胖和 25 名非肥胖性腺功能正常的静脉性勃起功能障碍患者以及 25 名健康对照者中测量了血清脂联素-2 和 CIMT。研究了它们与不同的患者和疾病相关参数的关系。结果表明，与非肥胖患者和对照组相比，肥胖患者的血清脂联素-2 显著升高，与非肥胖患者相比，对照组的血清脂联素-2 也升高。与肥胖和非肥胖患者相比，对照组的 CIMT 较低。在肥胖和非肥胖患者中，脂联素-2 与疾病持续时间、体重指数、腰围和舒张末期速度呈正相关。脂联素-2 与两组的国际勃起功能指数短表评分呈负相关。总之，肥胖患者和在一定程度上非肥胖患者中升高的脂联素-2 及其与疾病严重程度的关联表明其作为诊断标志物的潜在价值，以及作为一种可能的治疗靶点，可改善与勃起功能障碍相关的代谢紊乱。
