Plant Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Plant Sci. 2013 Dec;213:123-7. doi: 10.1016/j.plantsci.2013.09.007. Epub 2013 Sep 18.
Sub-toxic doses of many toxicants have positive, beneficial effects on productivity, or stress resistance (hormesis). Transcriptomic, proteomic, and metabolomic responses to a disparate variety hormetic agents, coupled with bioinformatic analyses, can be used to identify consensus genes, their controlling elements, and their metabolites related to stimulation of growth and/or health. This information can then be used as a method for generating healthier and higher yielding crops using transgenic or other biotechnological techniques. The same bioinformatic information can be used to develop knowledge-based, transcriptomic, proteomic and metabolomic high throughput pre-screens using young plants to identify hormetic chemicals that are potentially useful for enhancement of crop health and yield. Such pre-screens preclude the need to use whole plants through maturity. While the hormetic effectors themselves have to date been of limited direct utility, it is clear that they can be used to help pinpoint genes and chemicals that are potentially useful. This is superior to the presently used random screening or even "educated guess" screening of genes and chemicals.
许多有毒物质的亚毒性剂量对生产力或抗应激能力（应激反应）具有积极的有益作用。对各种不同的应激反应剂的转录组、蛋白质组和代谢组的反应，加上生物信息学分析，可用于鉴定与生长和/或健康刺激相关的共识基因、其调控元件及其代谢物。然后，可使用转基因或其他生物技术技术，将这些信息用作生成更健康和更高产作物的方法。相同的生物信息学信息可用于开发基于知识的、转录组学、蛋白质组学和代谢组学高通量预筛选，使用幼植物来鉴定潜在有益于增强作物健康和产量的应激反应性化学物质。这种预筛选排除了在整个植物成熟过程中使用整株植物的需要。虽然应激反应效应物本身迄今为止具有有限的直接用途，但很明显，它们可用于帮助确定潜在有用的基因和化学物质。这优于目前使用的随机筛选甚至是“有根据的猜测”筛选基因和化学物质。
