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在DeBakey I型急性主动脉夹层修复术中对降主动脉进行顺行支架置入术。

Antegrade stenting of the descending thoracic aorta during DeBakey type 1 acute aortic dissection repair.

作者信息

Di Eusanio Marco, Castrovinci Sebastiano, Tian David H, Folesani Gianluca, Cefarelli Mariano, Pantaleo Antonio, Murana Giacomo, Berretta Paolo, Yan Tristan D, Bartolomeo Roberto Di

机构信息

Department of Cardiac Surgery, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy The Collaborative Research (CORE) Group, Sydney, Australia

Department of Cardiac Surgery, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

出版信息

Eur J Cardiothorac Surg. 2014 Jun;45(6):967-75. doi: 10.1093/ejcts/ezt493. Epub 2013 Oct 24.

Abstract

Several studies have shown that after DeBakey type 1 acute aortic dissection (DB1-AAD) surgery, 70% of the surviving patients still present with a dissected distal aorta that can eventually dilate, rupture, lead to distal malperfusion or require secondary extensive interventions. In order to minimize these complications, different surgeons have advocated total thoracic aorta remodelling procedures during primary aortic repair to promote false-lumen obliteration and distal thrombosis. Such management, which includes arch replacement and antegrade stenting of the dissected descending thoracic aorta (DTA), remains controversial due to its perceived increased operative mortality. Furthermore, the desired long-term benefits remain to be confirmed. The present article aimed to evaluate results of antegrade stenting of DTA during surgery for DB1-AAD, focusing on in-hospital mortality and morbidity, and long-term survival, occurrence of distal aortic remodelling and freedom from aortic reinterventions. Early results from the identified studies suggested that hybrid repair of DB1-AAD with antegrade DTA stenting was associated with satisfactory in-hospital mortality (10.0%) and stroke (4.8%) rates, while the risk of spinal cord injury appeared to be higher (4.3%) than that reported from historical controls. Furthermore, antegrade stenting of DTA was associated with promising rates of partial/complete thrombosis of the peristent DTA false lumen (88.9%), suggesting that aortic remodelling is highly probable with this approach. Evidence on long-term results after proximal acute dissection repair is still sparse, and mostly jeopardized by limited data beyond 5 years. Further investigations with longer term follow-up and with specifically designed protocols to assess long-term clinical outcomes (late aortic mortality and freedom from distal aortic reinterventions) of total thoracic aortic remodelling procedures vs more conservative management are warranted to reach more definitive conclusions.

摘要

多项研究表明,在1型急性主动脉夹层(DB1-AAD)手术后,70%的存活患者仍存在远端主动脉夹层,最终可能会扩张、破裂、导致远端灌注不良或需要二次广泛干预。为了尽量减少这些并发症,不同的外科医生主张在初次主动脉修复时采用全胸主动脉重塑手术,以促进假腔闭塞和远端血栓形成。这种治疗方法包括主动脉弓置换和对夹层降主动脉(DTA)进行顺行支架置入,由于其被认为会增加手术死亡率,因此仍存在争议。此外,预期的长期益处仍有待证实。本文旨在评估DB1-AAD手术期间DTA顺行支架置入的结果,重点关注住院死亡率和发病率、长期生存率、远端主动脉重塑的发生情况以及无需再次进行主动脉干预。已确定研究的早期结果表明,DB1-AAD采用DTA顺行支架置入的杂交修复术,其住院死亡率(10.0%)和中风发生率(4.8%)令人满意,而脊髓损伤风险似乎高于历史对照报道的风险(4.3%)。此外,DTA顺行支架置入与持续性DTA假腔部分/完全血栓形成的发生率较高(88.9%)相关,这表明采用这种方法很可能实现主动脉重塑。近端急性夹层修复术后长期结果的证据仍然很少,而且大多受到5年以上有限数据的影响。有必要进行进一步的长期随访研究,并采用专门设计的方案来评估全胸主动脉重塑手术与更保守治疗相比的长期临床结果(晚期主动脉死亡率和无需进行远端主动脉再次干预),以得出更明确的结论。

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