[经皮加速部分乳腺照射（APBI）后出现不良美容效果和毒性的风险。加拿大RAPID试验的中期分析] - Suppr

[Risks of unfavorable cosmetic and toxicity after percutaneous accelerated partial breast irradiation (APBI). Interim analysis from the Canadian RAPID trial].

作者信息

Piroth M D

机构信息

Klinik für Radioonkologie und Strahlentherapie, Universitätsklinikum RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland,

出版信息

Strahlenther Onkol. 2013 Dec;189(12):1054-5. doi: 10.1007/s00066-013-0447-6.

DOI:10.1007/s00066-013-0447-6

PMID:24158635

Abstract

摘要

相似文献

[Risks of unfavorable cosmetic and toxicity after percutaneous accelerated partial breast irradiation (APBI). Interim analysis from the Canadian RAPID trial].[经皮加速部分乳腺照射（APBI）后出现不良美容效果和毒性的风险。加拿大RAPID试验的中期分析]

Strahlenther Onkol. 2013 Dec;189(12):1054-5. doi: 10.1007/s00066-013-0447-6.

Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy.RAPID 研究的中期美容和毒性结果：一项使用三维适形外照射放射治疗加速部分乳房照射的随机试验。

J Clin Oncol. 2013 Nov 10;31(32):4038-45. doi: 10.1200/JCO.2013.50.5511. Epub 2013 Jul 8.

External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial.保乳手术后局部晚期导管原位癌和淋巴结阴性乳腺癌患者行体外加速部分乳房照射与全乳房照射的对比（RAPID）：一项随机对照试验。

Lancet. 2019 Dec 14;394(10215):2165-2172. doi: 10.1016/S0140-6736(19)32515-2. Epub 2019 Dec 5.

Predictors of adverse cosmetic outcome in the RAPID trial: an exploratory analysis.RAPID试验中不良美容结局的预测因素：一项探索性分析。

Int J Radiat Oncol Biol Phys. 2015 Apr 1;91(5):968-76. doi: 10.1016/j.ijrobp.2014.12.040.

Higher toxicity with 42 Gy in 10 fractions as a total dose for 3D-conformal accelerated partial breast irradiation: results from a dose escalation phase II trial.对于 3D 适形加速部分乳房照射，总剂量为 42 Gy 的 10 个分数，毒性更高：来自剂量递增 II 期试验的结果。

Radiat Oncol. 2012 Aug 22;7:141. doi: 10.1186/1748-717X-7-141.

Should low-risk patients be treated with three-dimensional conformal radiation therapy-accelerated partial-breast irradiation in an off-protocol setting?低风险患者是否应在非方案设定下接受三维适形放射治疗-加速部分乳腺照射？

J Clin Oncol. 2013 Nov 10;31(32):4032-7. doi: 10.1200/JCO.2013.51.1642. Epub 2013 Sep 30.

5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial.5 年结果：保乳手术后采用单纯间质内多导管近距离放疗与全乳放疗加局部推量治疗低危型女性乳腺浸润性癌和原位癌的对比：一项随机、3 期、非劣效性试验。

Lancet. 2016 Jan 16;387(10015):229-38. doi: 10.1016/S0140-6736(15)00471-7. Epub 2015 Oct 19.

Accelerated partial breast irradiation using 3D conformal radiotherapy: toxicity and cosmetic outcome.使用三维适形放疗的加速部分乳腺照射：毒性和美容效果。

Breast. 2013 Dec;22(6):1136-41. doi: 10.1016/j.breast.2013.07.042. Epub 2013 Aug 16.

Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy.在接受保乳治疗的早期乳腺癌患者中，使用三维适形外照射放疗进行加速部分乳腺照射的中期美容效果和毒性。

Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1124-30. doi: 10.1016/j.ijrobp.2007.04.033.

Three-year outcomes of a Canadian multicenter study of accelerated partial breast irradiation using conformal radiation therapy.加拿大应用适形放射疗法加速部分乳腺照射多中心研究的 3 年结果。

Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1220-7. doi: 10.1016/j.ijrobp.2010.07.2003. Epub 2010 Oct 23.

引用本文的文献

To clip or not to clip the breast tumor bed? A retrospective look at the geographic miss index and normal tissue index of 110 patients with breast cancer.是否对乳腺肿瘤床进行夹闭？对110例乳腺癌患者的地理遗漏指数和正常组织指数的回顾性研究。

J Turk Ger Gynecol Assoc. 2017 Jun 1;18(2):67-71. doi: 10.4274/jtgga.2016.0222. Epub 2017 Feb 7.

本文引用的文献

J Clin Oncol. 2013 Nov 10;31(32):4038-45. doi: 10.1200/JCO.2013.50.5511. Epub 2013 Jul 8.

Reports of unexpected late side effects of accelerated partial breast irradiation--radiobiological considerations.加速部分乳腺照射意外晚期副作用的报告——放射生物学考量

Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):969-73. doi: 10.1016/j.ijrobp.2010.01.059.

Unacceptable cosmesis in a protocol investigating intensity-modulated radiotherapy with active breathing control for accelerated partial-breast irradiation.主动呼吸控制调强放疗加速部分乳腺照射方案中不可接受的美容效果。

Int J Radiat Oncol Biol Phys. 2010 Jan 1;76(1):71-8. doi: 10.1016/j.ijrobp.2009.01.041.

Toxicity of three-dimensional conformal radiotherapy for accelerated partial breast irradiation.三维适形放疗用于加速部分乳腺照射的毒性

Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1290-6. doi: 10.1016/j.ijrobp.2009.01.009. Epub 2009 Apr 22.

Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer.淋巴结阴性乳腺癌患者保乳术后乳房照射方案的随机试验

J Natl Cancer Inst. 2002 Aug 7;94(15):1143-50. doi: 10.1093/jnci/94.15.1143.

Repair halftimes estimated from observations of treatment-related morbidity after CHART or conventional radiotherapy in head and neck cancer.根据对头颈部癌患者进行加速超分割放疗（CHART）或传统放疗后与治疗相关的发病率观察结果估算的修复半衰期。

Radiother Oncol. 1999 Dec;53(3):219-26. doi: 10.1016/s0167-8140(99)00151-6.

Repair capacity and kinetics for human mucosa and epithelial tumors in the head and neck: clinical data on the effect of changing the time interval between multiple fractions per day in radiotherapy.

Radiother Oncol. 1996 Feb;38(2):89-101. doi: 10.1016/0167-8140(95)01689-9.

Evaluation of breast conserving therapy: clinical, methodological and psychosocial perspectives.

Eur J Surg Oncol. 1988 Apr;14(2):133-40.

Quality of life in stage II breast cancer: an instrument for clinical trials.II期乳腺癌患者的生活质量：一种用于临床试验的工具。

J Clin Oncol. 1988 Dec;6(12):1798-810. doi: 10.1200/JCO.1988.6.12.1798.

Is the experience with CHART compatible with experimental data? A new model of repair kinetics and computer simulations.

Radiother Oncol. 1992 Dec;25(4):280-6. doi: 10.1016/0167-8140(92)90248-s.

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[Risks of unfavorable cosmetic and toxicity after percutaneous accelerated partial breast irradiation (APBI). Interim analysis from the Canadian RAPID trial].

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