Uddman R, Edvinsson L, Ekman R, Kingman T, McCulloch J
Neurosci Lett. 1985 Nov 20;62(1):131-6. doi: 10.1016/0304-3940(85)90296-4.
The presence of a population of nerve fibers containing immunoreactive calcitonin gene-related peptide (CGRP) has been demonstrated around cerebral arteries of the cat with immunocytochemistry and radioimmunoassay. CGRP immunoreactivity in the feline cerebral vasculature, as characterized by high-performance liquid chromatography, is similar to authentic rat CGRP. Numerous perikarya containing CGRP are present in the trigeminal ganglia, and surgical lesions of the trigeminal ganglia significantly reduce the levels of CGRP in the cerebral vasculature, suggesting that this cranial nerve is the principal origin of these cerebrovascular nerve fibers. As demonstrated by sequential immunocytochemistry, CGRP coexists with substance P both in the trigeminal ganglion and nerve fibers around cerebral blood vessels. The presence of CGRP in the cerebrovascular trigeminal innervation provides further versatility and complexity for this sensory afferent system putatively involved in the transmission of intracranial pain.
利用免疫细胞化学和放射免疫测定法已证实，猫脑动脉周围存在一群含有免疫反应性降钙素基因相关肽（CGRP）的神经纤维。通过高效液相色谱法表征，猫脑血管中的CGRP免疫反应性与正宗大鼠CGRP相似。三叉神经节中存在大量含有CGRP的神经周体，三叉神经节的手术损伤显著降低了脑血管中CGRP的水平，这表明该颅神经是这些脑血管神经纤维的主要起源。连续免疫细胞化学显示，CGRP在三叉神经节和脑血周围神经纤维中均与P物质共存。脑血管三叉神经支配中CGRP的存在为这个可能参与颅内痛觉传递的感觉传入系统提供了更多的多样性和复杂性。
