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2/100Hz 电针对 responder 大鼠的抗伤害性脊髓机制的激活与 2Hz 和 100Hz 电针的激活不同。

Electroacupuncture at 2/100 hz activates antinociceptive spinal mechanisms different from those activated by electroacupuncture at 2 and 100 hz in responder rats.

机构信息

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenue Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil.

出版信息

Evid Based Complement Alternat Med. 2013;2013:205316. doi: 10.1155/2013/205316. Epub 2013 Sep 16.

DOI:10.1155/2013/205316
PMID:24159340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3789442/
Abstract

We examined the effects of intrathecal injection of desipramine and fluoxetine (selective inhibitors of norepinephrine and 5-HT uptake, resp.), thiorphan and neostigmine (inhibitors of enkephalinase and acetylcholinesterase, resp.), gabapentin (a GABA releaser), and vigabatrin (an inhibitor of GABA-transaminase) on the antinociception induced by 2 Hz, 100 Hz, or 2/100 Hz electroacupuncture (EA) applied bilaterally to the Zusanli (ST36) and Sanyinjiao (SP6) acupoints using the rat tail-flick test. We show that 2 Hz EA antinociception lasts longer after the administration of drugs that increase the spinal availability of norepinephrine, acetylcholine, or GABA; 100 Hz EA antinociception lasts longer after drug that increases the spinal availability of norepinephrine; 2/100 Hz EA antinociception lasts longer after drugs that increase the spinal availability of endogenous opioids or GABA. We conclude that the antinociceptive effect of 2/100 Hz EA is different from the synergistic effect of alternate stimulation at 2 and 100 Hz because the effect of the former is not changed by increasing the spinal availability of serotonin and lasts longer after the administration of vigabatrin. The combination of EA with drugs that increase the availability of spinal neurotransmitters involved in the modulation of nociceptive inputs may result in a synergistic antinociceptive effect in the rat tail-flick test.

摘要

我们考察了鞘内注射去甲丙咪嗪和氟西汀（分别为去甲肾上腺素和 5-羟色胺摄取的选择性抑制剂）、硫普罗宁和新斯的明（分别为脑啡肽酶和乙酰胆碱酯酶抑制剂）、加巴喷丁（GABA 释放剂）和氨己烯酸（GABA 转氨酶抑制剂）对双侧电针（EA）刺激足三里（ST36）和三阴交（SP6）穴位引起的 2 Hz、100 Hz 或 2/100 Hz 镇痛作用的影响，采用大鼠甩尾试验。结果显示，鞘内给予增加去甲肾上腺素、乙酰胆碱或 GABA 脊髓可利用度的药物后，2 Hz EA 镇痛作用持续时间延长；鞘内给予增加去甲肾上腺素脊髓可利用度的药物后，100 Hz EA 镇痛作用持续时间延长；鞘内给予增加内源性阿片肽或 GABA 脊髓可利用度的药物后，2/100 Hz EA 镇痛作用持续时间延长。由此得出结论，2/100 Hz EA 的镇痛作用不同于 2 和 100 Hz 交替刺激的协同作用，因为前者的作用不受增加 5-羟色胺脊髓可利用度的影响，且在给予氨己烯酸后作用持续时间延长。电针联合增加参与调制痛觉传入的脊髓神经递质可利用度的药物可能在大鼠甩尾试验中产生协同镇痛作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76bb/3789442/24cdcd6306d8/ECAM2013-205316.008.jpg
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