Sector of Dermatology, School of Medical Sciences and University Hospital, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Clin Dermatol. 2013 Nov-Dec;31(6):741-9. doi: 10.1016/j.clindermatol.2013.05.012.
Heinrich Koebner (1838-1904) presented in a meeting in 1872 and reported in 1877 the emergence of psoriatic lesions following trauma to healthy skin areas of patients with psoriasis. Since then, the Koebner phenomenon has been the subject of research, as it offers a unique opportunity in the investigation of the disease, especially in experimental studies, when this dermatosis may be observed in all its phases. Establishing the differences between Koebner, Wolf, Renbök, reverse Koebner, pseudo-Koebner phenomena, and pathergy is sometimes unclear. We review the various aspects of the Koebner phenomenon's clinical description and presentation, pathophysiology, histopathology, reverse phenomenon, therapeutic treatments, and prevention.
海因里希·科布纳（Heinrich Koebner）于 1872 年在一次会议上提出，并于 1877 年报告称，银屑病患者健康皮肤区域受到创伤后会出现银屑病病变。从那时起，科布纳现象一直是研究的主题，因为它为疾病的研究提供了一个独特的机会，尤其是在实验研究中，此时可以观察到这种皮肤病的所有阶段。确定科布纳、沃尔夫、伦博克、反向科布纳、假性科布纳现象和触发性之间的差异有时并不明确。我们回顾了科布纳现象的临床描述和表现、病理生理学、组织病理学、反向现象、治疗方法和预防等各个方面。
