Department of Dermatology, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.
Clin Dermatol. 2011 Mar-Apr;29(2):231-6. doi: 10.1016/j.clindermatol.2010.09.014.
The Koebner phenomenon is one of the most well-known entities in dermatology. It was first described by Heinrich Koebner in 1876 as the formation of psoriatic lesions in uninvolved skin of psoriatic patients after cutaneous trauma. This isomorphic phenomenon is now known to involve numerous diseases, among them vitiligo, lichen planus, and Darier disease. The pathogenesis of the Koebner phenomenon is still obscure but may involve cytokines, stress proteins, adhesion molecules, and autoantigens. This contribution reviews the clinical manifestations of Koebner phenomenon, its provocative factors, suggested pathogenesis mechanisms, and the various skin conditions that exhibit this unique response.
科布纳现象是皮肤病学中最著名的现象之一。它于 1876 年由 Heinrich Koebner 首次描述，指的是在皮肤创伤后，无银屑病皮损的银屑病患者的皮肤中形成银屑病样皮损。这种同形反应现象现在已知涉及许多疾病，包括白癜风、扁平苔藓和 Darier 病。科布纳现象的发病机制仍不清楚，但可能涉及细胞因子、应激蛋白、黏附分子和自身抗原。本文综述了科布纳现象的临床表现、诱发因素、发病机制假说以及表现出这种独特反应的各种皮肤疾病。
