Anderson C, Groth O
Acta Derm Venereol. 1985;65(5):403-8.
Single intraperitoneal injections of cyclophosphamide were administered 6 days before testing guinea pigs sensitized to oxazolone in order to study the effects on inflammatory cell populations in blood and dermis. Skin tests were assessed macroscopically (erythema and oedema) and microscopically (counting of the dermal inflammatory cell infiltrate). At the highest dose (300 mg/kg) the allergic contact reaction was augmented with increases in erythema and oedema and the mononuclear dermal infiltrate. At the lowest dose (75 mg/kg), redness and oedema and all components of the dermal inflammatory cell infiltrate decreased. Total and differential white blood counts up to 20 days after administration of cyclophosphamide showed that a dose-dependent leukopenia maximal around 6 days occurred. During the leukopenia the differential count showed a lymphocytosis with a marked granulocyte depletion. The augmentation of the contact allergic reaction produced at the highest dose of cyclophosphamide occurs despite a marked peripheral blood leukopenia. Cyclophosphamide's effects at the lower dose would appear to be of a non-specific anti-inflammatory nature.
在对恶唑酮致敏的豚鼠进行测试前6天，腹腔注射一次环磷酰胺，以研究其对血液和真皮中炎症细胞群的影响。皮肤试验通过肉眼（红斑和水肿）和显微镜（真皮炎症细胞浸润计数）进行评估。在最高剂量（300mg/kg）时，过敏接触反应增强，红斑、水肿及真皮单核细胞浸润增加。在最低剂量（75mg/kg）时，红斑、水肿及真皮炎症细胞浸润的所有成分均减少。环磷酰胺给药后长达20天的白细胞总数和分类计数显示，出现了剂量依赖性白细胞减少，在约6天时达到最大程度。在白细胞减少期间，分类计数显示淋巴细胞增多，伴有明显的粒细胞减少。尽管外周血白细胞明显减少，但环磷酰胺最高剂量仍产生了接触性过敏反应增强。环磷酰胺在较低剂量时的作用似乎具有非特异性抗炎性质。
