Fehlmann M, Chvatchko Y, Brandenburg D, Van Obberghen E, Brossette N
Biochimie. 1985 Oct-Nov;67(10-11):1155-9. doi: 10.1016/s0300-9084(85)80114-0.
Insulin receptors were labeled with 125I-photoreactive insulin (specifically labeling alpha-subunits) and by insulin-stimulated autophosphorylation (specifically labeling beta-subunits). The results show that the insulin receptor exists under different free and disulfide-linked combinations of alpha and beta subunits. Moreover, the insulin receptor is closely associated to class I antigens of the major histocompatibility complex to form a high molecular weight multi-molecular membrane complex.
胰岛素受体用125I-光反应性胰岛素标记（特异性标记α亚基），并通过胰岛素刺激的自身磷酸化作用（特异性标记β亚基）进行标记。结果表明，胰岛素受体以α和β亚基的不同游离和二硫键连接组合形式存在。此外，胰岛素受体与主要组织相容性复合体的I类抗原紧密相关，形成高分子量的多分子膜复合物。
