通过骨桥蛋白表达评估四角葡萄的成骨潜力。
Osteogenic potential of cissus qudrangularis assessed with osteopontin expression.
作者信息
Singh Nimisha, Singh Vibha, Singh R K, Pant A B, Pal U S, Malkunje Laxman R, Mehta Gagan
机构信息
Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.
出版信息
Natl J Maxillofac Surg. 2013 Jan;4(1):52-6. doi: 10.4103/0975-5950.117884.
PURPOSE
Fracture healing involves complex processes of cell and tissue proliferation and differentiation. Many factors are involved, including growth factors, inflammatory cytokines, antioxidants, bone breakdown (osteoclast) and bone building (osteoblast) cells, hormones, amino acids, and uncounted nutrients. We studied the osteogenic potential of Cissus quadrangularis (CQ), a plant that has been customarily used in the Indian subcontinent to hasten the process of healing in bone fractures.
MATERIALS AND METHODS
Total of 60 patients (age, 20-35 years) of mandible fracture was divided in two groups. Patients of group 1 were given capsules of CQ and fracture healing was assessed with osteopontin expression during treatment. Group 2 was control group.
RESULTS
Clinical and radiological analysis in our study was suggestive of better healing of fractures in group 1. All the samples of group 1 examined for osteopontin expression using western blot analysis and flow cytometry showed significant levels of expression of osteopontin protein and CD4+ T cells expressing osteopontin, respectively.
CONCLUSION
We conclude that CQ accelerates fracture healing and also causes early remodeling of fracture callus.
目的
骨折愈合涉及细胞和组织增殖与分化的复杂过程。其中涉及许多因素，包括生长因子、炎性细胞因子、抗氧化剂、骨吸收（破骨细胞）和骨形成（成骨细胞）细胞、激素、氨基酸以及无数的营养素。我们研究了四角葡萄（CQ）的成骨潜力，该植物在印度次大陆一直被用于加速骨折愈合过程。
材料与方法
将60例下颌骨骨折患者（年龄20 - 35岁）分为两组。第1组患者服用CQ胶囊，并在治疗期间通过骨桥蛋白表达评估骨折愈合情况。第2组为对照组。
结果
我们研究中的临床和影像学分析表明，第1组骨折愈合情况更好。使用蛋白质印迹分析和流式细胞术检测第1组所有样本的骨桥蛋白表达，结果分别显示骨桥蛋白和表达骨桥蛋白的CD4 + T细胞有显著水平的表达。
结论
我们得出结论，CQ可加速骨折愈合，并导致骨折痂的早期重塑。
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