免疫功能正常的患者会患进行性多灶性白质脑病吗？
Progressive multifocal leukoencephalopathy in an immunocompetent patient?
作者信息
Johansen Krisztina K, Torp Sverre H, Rydland Jana, Aasly Jan O
机构信息
Department of Neurology, St Olavs University Hospital, Trondheim, Norway ; Department of Neuroscience, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
出版信息
Case Rep Neurol. 2013 Sep 4;5(3):149-54. doi: 10.1159/000354828. eCollection 2013.
BACKGROUND
Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive, potentially fatal, demyelinating disease affecting immunosuppressed patients. PML is rarely reported in cases with no underlying disease or immunosuppression-associated condition.
CASE REPORT
We present a 72-year-old previously healthy woman who developed a progressive neurological condition affecting the entire nervous system which led to her death within 5 months. PML was diagnosed at autopsy.
CONCLUSION
PML should be considered in patients with progressive neurological disorders involving the white matter, even in the absence of previous immunomodulatory treatment or immunosuppression.
背景
进行性多灶性白质脑病（PML）是一种快速进展、可能致命的脱髓鞘疾病，影响免疫抑制患者。在没有潜在疾病或免疫抑制相关疾病的病例中，PML很少被报道。
病例报告
我们报告一名72岁既往健康的女性，她出现了影响整个神经系统的进行性神经疾病，并在5个月内死亡。尸检诊断为PML。
结论
对于出现涉及白质的进行性神经障碍的患者，即使没有先前的免疫调节治疗或免疫抑制，也应考虑PML。
Zotero 插件