胆碱酯酶与对氧磷酶 1 活性的相关性：农药中毒病例系列。
Correlation between Cholinesterase and Paraoxonase 1 Activities:Case Series of Pesticide Poisoning Subjects.
机构信息
Department of Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India.
出版信息
Bioimpacts. 2013;3(3):119-22. doi: 10.5681/bi.2013.024. Epub 2013 Aug 25.
INTRODUCTION
Acute exposure to pesticide due to suicidal poisoning is the most extensive cause of pesticide exposure, compared with all other causes including agricultural or industrial exposure. Organophosphate (OP) and carbamate group of pesticides can inhibit acetylcholinesterase; on the other hand, paraoxonase1 can detoxify organophosphate poisoning by hydrolyzing organophosphate metabolites.
METHODS
We have compared the serum paraoxonase1 status and cholinesterase activity of subjects who attempted to commit suicide by consuming OP pesticide. Cholinesterase and paraoxonase1 activity were measured spectrophotometrically using butyrylthiocholine and phenyl acetate as substrates, respectively.
RESULTS
A positive correlation was found between serum paraoxonase1 activity and cholinesterase activity among pesticide consumed subjects.
CONCLUSION
Our results suggest that subjects with higher paraoxonase1 activity may have a better chance of detoxifying the lethal effect of acute organophosphate poisoning.
简介
与包括农业或工业接触在内的所有其他原因相比，由于自杀性中毒而导致的急性接触农药是最广泛的农药接触原因。有机磷（OP）和氨基甲酸酯类农药可以抑制乙酰胆碱酯酶；另一方面，对氧磷酶 1 可以通过水解有机磷代谢物来解毒有机磷中毒。
方法
我们比较了因摄入 OP 类农药而试图自杀的患者的血清对氧磷酶 1 状态和胆碱酯酶活性。使用丁酰硫代胆碱和苯乙酸酯作为底物，通过分光光度法测量胆碱酯酶和对氧磷酶 1 活性。
结果
在摄入农药的患者中，血清对氧磷酶 1 活性与胆碱酯酶活性之间存在正相关关系。
结论
我们的结果表明，具有较高对氧磷酶 1 活性的患者可能有更好的机会消除急性有机磷中毒的致命影响。
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