Il'iuchenok T Iu, Khomenko A I, Frigidova L M, Lepekhin V P, Verkhovskiĭ Iu G
Farmakol Toksikol. 1975 Sep-Oct;38(5):607-12.
In experiments set up on mice, rats and guinea pigs 8 gamma-pyron derivatives were studied. They proved to be little toxic, do not change significantly the arterial pressure and respiration, exercise a depressing action on the central nervous system, produce a marked antiphlogistic (normal and irradiated animals), radio-protective and antihistaminic effects and influence norephinephrine, homovanillic acid and dopamine metabolism in the brain.
在针对小鼠、大鼠和豚鼠开展的实验中,对8种γ-吡喃衍生物进行了研究。结果表明它们毒性很小,不会显著改变动脉血压和呼吸,对中枢神经系统有抑制作用,具有明显的抗炎作用(对正常动物和受辐照动物均有效)、放射防护作用和抗组胺作用,并会影响大脑中去甲肾上腺素、高香草酸和多巴胺的代谢。