全基因组关联研究荟萃分析将TSNARE1鉴定为一个新的精神分裂症/双相情感障碍易感性基因座。
GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus.
作者信息
Sleiman Patrick, Wang Dai, Glessner Joseph, Hadley Dexter, Gur Raquel E, Cohen Nadine, Li Qingqin, Hakonarson Hakon
机构信息
1] The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA [2] Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
出版信息
Sci Rep. 2013 Oct 29;3:3075. doi: 10.1038/srep03075.
We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(-9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.
我们对合并的混合血统精神分裂症、分裂情感性障碍和双相情感障碍队列进行了全基因组关联研究（GWAS）荟萃分析，结果鉴定出6个全基因组显著位点，其中包括位于8号染色体q24.3区域的一个新位点，该位点包含TSNARE1基因（P = 1.28 × 10⁻⁹）。该分析共纳入了13394例病例和34676例对照。虽然TSNARE1的功能尚不清楚，但基于系统发育谱系的生物信息学预测表明，它可能在脊椎动物细胞内蛋白质运输和突触小泡胞吐作用中具有特定功能。
Zotero 插件