Unreliability in the estimation of the molecular weight of fibrinogen degradation products (FDPs) by polyacrylamide/sodium dodecyl sulphate electrophoresis (SDS/PAGE).

Evidence is presented indicating that using different SDS/PAGE techniques the molecular weight estimation and the appearance of fibrinogen degradation products on the gel may vary according to the type used. It is suggested that changes in the structure and shape of the fragments, due to asymmetry in the degradation, may explain the differences.