具有线性甘露聚糖的脂多糖（LPS）在LPS抗性C3H/HeJ小鼠中的佐剂作用。

Adjuvant actions of linear mannan-possessing lipopolysaccharide (LPS) in LPS-resistant C3H/HeJ mice.

作者信息

Ohta M, Kido N, Nakashima I, Kato N

出版信息

Immunology. 1985 Nov;56(3):571-3.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453756/

Abstract

Immunopotentiation has been demonstrated when Klebsiella O3 lipopolysaccharide (KO3 LPS), which possesses a linear mannan as the O-specific side chain, was injected subcutaneously into endotoxin resistant C3H/HeJ mice together with soluble protein antigens. The LPS exhibited significantly positive adjuvant effects on antibody responses in vivo after secondary antigen challenge and on delayed-type hypersensitivity (DTH) reactions against protein antigens. However, KO3 LPS was not a polyclonal B cell activator (PBA) in C3H/HeJ mice nor mitogenic in cultures of spleen cells of C3H/HeJ. Thus, the activity of the LPS in C3H/HeJ mice is confined to the potentiation of T-dependent immune responses. The contribution of the mannan O side chain to the adjuvant action of KO3 LPS was suggested.

摘要

当具有线性甘露聚糖作为O特异性侧链的肺炎克雷伯菌O3脂多糖（KO3 LPS）与可溶性蛋白抗原一起皮下注射到对内毒素有抗性的C3H/HeJ小鼠体内时，已证明有免疫增强作用。在二次抗原攻击后，LPS对体内抗体反应以及对蛋白质抗原的迟发型超敏反应（DTH）表现出显著的阳性佐剂效应。然而，KO3 LPS在C3H/HeJ小鼠中不是多克隆B细胞激活剂（PBA），在C3H/HeJ小鼠的脾细胞培养物中也没有促有丝分裂作用。因此，LPS在C3H/HeJ小鼠中的活性仅限于增强T细胞依赖性免疫反应。提示了甘露聚糖O侧链对KO3 LPS佐剂作用的贡献。

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2

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本文引用的文献

1

Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

J Biol Chem. 1951 Nov;193(1):265-75.

2

Adjuvant action of bacterial lipopolysaccharide in induction of delayed-type hypersensitivity to protein antigens. II. Relationships of intensity of the action to that of other immunological activities.细菌脂多糖在诱导对蛋白质抗原的迟发型超敏反应中的佐剂作用。II. 该作用强度与其他免疫活性强度的关系。

Immunobiology. 1982 Dec;163(5):460-9. doi: 10.1016/S0171-2985(82)80060-0.

3

Correlation between strong adjuvanticity of Klebsiella O3 lipopolysaccharide and its ability to induce interleukin-1 secretion.肺炎克雷伯菌O3脂多糖的强佐剂活性与其诱导白细胞介素-1分泌能力之间的相关性。

Cell Immunol. 1984 May;85(2):477-86. doi: 10.1016/0008-8749(84)90260-0.

4

Adjuvant activity of Klebsiella O3 lipopolysaccharide: inhibition of the adjuvant activity by concanavalin A.肺炎克雷伯菌O3脂多糖的佐剂活性：伴刀豆球蛋白A对其佐剂活性的抑制作用

Microbiol Immunol. 1985;29(3):205-11. doi: 10.1111/j.1348-0421.1985.tb00820.x.

5

Comparative studies on adjuvanticity of Klebsiella O3 lipopolysaccharide and its lipid A and polysaccharide fractions.肺炎克雷伯菌O3脂多糖及其脂质A和多糖组分佐剂活性的比较研究。

Immunology. 1985 Feb;54(2):317-24.

6

Potent adjuvant action of lipopolysaccharides possessing the O-specific polysaccharide moieties consisting of mannans in antibody response against protein antigen.

Cell Immunol. 1985 Mar;91(1):52-9. doi: 10.1016/0008-8749(85)90031-0.

7

Cellular requirements for lipopolysaccharide adjuvanticity. A role for both T lymphocytes and macrophages for in vitro responses to particulate antigens.脂多糖佐剂活性的细胞需求。T淋巴细胞和巨噬细胞在体外对颗粒性抗原应答中的作用。

J Exp Med. 1979 Apr 1;149(4):793-807. doi: 10.1084/jem.149.4.793.

8

Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages.肺泡巨噬细胞对糖蛋白、糖缀合物和溶酶体糖苷酶进行受体介导结合的证据。

Proc Natl Acad Sci U S A. 1978 Mar;75(3):1399-403. doi: 10.1073/pnas.75.3.1399.

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