Rao Cui, Lin Shan-Li, Wen Huan, Deng Hong
Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2013 Sep;42(5):591-6. doi: 10.3785/j.issn.1008-9292.2013.05.019.
TGF-β signaling pathway plays a central role in the signaling networks that control the growth, differentiation of the cell, and the initiation of fibrosis and cancer. Wnt signaling pathway is critical for the embryonic development and the invasion and migration of cancer cells. TGF-β signaling and Wnt signaling, both of which play an important role in regulating embryonic development, fibrotic disease and tumor progression, have a close relationship. Researches find several typical cross points between these two signaling systems, such as Smad, Axin, Dvl and β-catenin. In this review, we focus on the crosstalk between TGF-β signaling and Wnt signaling through these typical factors, intending to better understand the process of fibrosis and tumor progression.
转化生长因子-β（TGF-β）信号通路在控制细胞生长、分化以及纤维化和癌症发生的信号网络中起着核心作用。Wnt信号通路对于胚胎发育以及癌细胞的侵袭和迁移至关重要。TGF-β信号通路和Wnt信号通路在调节胚胎发育、纤维化疾病和肿瘤进展中均发挥重要作用，二者关系密切。研究发现这两种信号系统之间存在几个典型的交叉点，如Smad、Axin、Dvl和β-连环蛋白。在本综述中，我们聚焦于通过这些典型因子介导的TGF-β信号通路与Wnt信号通路之间的相互作用，旨在更好地理解纤维化和肿瘤进展过程。
