Institute of Normal and Pathological Physiology and Centre of Excellence for Regulatory Role of Nitric Oxide in Civilisation Diseases, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovakia ; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's Faculty Hospital and Masaryk University, Pekarska 53, 602 00 Brno, Czech Republic.
Dis Markers. 2013;35(5):287-93. doi: 10.1155/2013/731609. Epub 2013 Sep 12.
The renin-angiotensin system is involved in the pathogenesis of coronary artery disease and myocardial infarction (MI). Angiotensin II (Ang II) has many adverse effects such as vasoconstriction and vascular remodeling, and these actions are mediated by the angiotensin II type 1 receptor (AT1R).
A total of 1376 patients were recruited from January 2010 to April 2012. The study group consisted of 749 patients with ACS (317 females and 432 males) and of 627 healthy controls.
The ACS patients demonstrated a lower proportion of AA genotypes and AC genotypes but higher proportions of CC genotypes than the control population. The AT1R CC genotype conferred a 2.76-fold higher risk of MI compared with the genotype AC and AA. In addition, the CC genotype was also associated with a 4.08 times higher risk of left anterior descending artery infarction and a 3.07 times higher risk of anterior wall infarction. We also found that the CC genotype was independently associated with sudden cardiac death.
This study demonstrated that the AT1R CC genotype is an independent risk factor for ACS incidence, and this genotype is associated with a greater ACS severity and greater risk of sudden cardiac death.
肾素-血管紧张素系统参与冠心病和心肌梗死（MI）的发病机制。血管紧张素 II（Ang II）具有血管收缩和血管重塑等多种不良反应，这些作用是通过血管紧张素 II 型 1 受体（AT1R）介导的。
2010 年 1 月至 2012 年 4 月共招募了 1376 名患者。研究组包括 749 名 ACS 患者（317 名女性和 432 名男性）和 627 名健康对照组。
ACS 患者的 AA 基因型和 AC 基因型比例较低，CC 基因型比例较高。与基因型 AC 和 AA 相比，AT1R CC 基因型使 MI 的风险增加 2.76 倍。此外，CC 基因型还与前降支梗死风险增加 4.08 倍和前壁梗死风险增加 3.07 倍相关。我们还发现 CC 基因型与心脏性猝死独立相关。
本研究表明，AT1R CC 基因型是 ACS 发病的独立危险因素，该基因型与 ACS 严重程度增加和心脏性猝死风险增加相关。
