Lambor D V, Das C P, Goel H C, Tiwari M, Lambor S D, Fegade M V
Department of Ear, Nose, Throat and Head and Neck Surgery, Goa Medical College and Hospital, India.
J Laryngol Otol. 2013 Nov;127(11):1071-7. doi: 10.1017/S0022215113002259. Epub 2013 Oct 29.
Necrotising otitis externa, which is typically seen in elderly diabetics, is a severe infective disorder caused by Pseudomonas aeruginosa. There is lack of standard management policy for necrotising otitis externa, hence this study attempted to frame a protocol for management based on clinical parameters.
A retrospective study of 27 patients with necrotising otitis externa was conducted over 6 years in a tertiary care hospital. Data were analysed with regards to demographic characteristics, clinical features, investigations, staging and treatment modalities.
Out of 27 patients, 26 were diabetics. The commonest organism isolated was P aeruginosa, which was sensitive to third generation cephalosporins and fluoroquinolones. Nine patients had cranial nerve involvement. Twelve of 15 patients treated with medical therapy recovered, as did 11 of 12 patients that underwent surgery.
A high index of suspicion, early diagnosis and prompt intervention are key factors to decrease morbidity and mortality. Fluoroquinolones, third generation cephalosporins and surgical debridement are the mainstay of treatment.
坏死性外耳道炎通常见于老年糖尿病患者,是由铜绿假单胞菌引起的一种严重感染性疾病。目前缺乏针对坏死性外耳道炎的标准管理策略,因此本研究试图根据临床参数制定一套管理方案。
在一家三级医院对27例坏死性外耳道炎患者进行了为期6年的回顾性研究。分析了患者的人口统计学特征、临床特征、检查、分期和治疗方式等数据。
27例患者中,26例为糖尿病患者。最常分离出的病原体是铜绿假单胞菌,该菌对第三代头孢菌素和氟喹诺酮类药物敏感。9例患者出现脑神经受累。接受药物治疗的15例患者中有12例康复,接受手术治疗的12例患者中有11例康复。
高度怀疑、早期诊断和及时干预是降低发病率和死亡率的关键因素。氟喹诺酮类药物、第三代头孢菌素和手术清创是主要的治疗方法。