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本文引用的文献

1
Characterization of the EP receptor types that mediate longitudinal smooth muscle contraction of human colon, mouse colon and mouse ileum.鉴定介导人结肠、鼠结肠和鼠回肠纵行平滑肌收缩的 EP 受体类型。
Neurogastroenterol Motil. 2011 Aug;23(8):782-e336. doi: 10.1111/j.1365-2982.2011.01727.x. Epub 2011 May 24.
2
Prostaglandin E2-prostanoid EP3 signal induces vascular contraction via nPKC and ROCK activation in rat mesenteric artery.前列腺素 E2-前列腺素 EP3 信号通过 nPKC 和 ROCK 的激活诱导大鼠肠系膜动脉的血管收缩。
Eur J Pharmacol. 2011 Jun 25;660(2-3):375-80. doi: 10.1016/j.ejphar.2011.03.032. Epub 2011 Apr 2.
3
Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2.肠阻塞运动功能障碍的病理生理学：牵张诱导的 COX-2 的作用。
Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G99-G108. doi: 10.1152/ajpgi.00379.2010. Epub 2010 Nov 4.
4
Propionate-induced epithelial K(+) and Cl(-)/HCO3(-) secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon.丙酸诱导豚鼠结肠远端上皮细胞钾离子和氯离子/碳酸氢根离子分泌及游离脂肪酸受体 2（FFA2，GPR43）表达。
Pflugers Arch. 2011 Jan;461(1):141-52. doi: 10.1007/s00424-010-0889-y. Epub 2010 Oct 14.
5
Immunohistochemical characteristics of submucosal Dogiel type II neurons in rat colon.大鼠结肠黏膜下 Dogiel Ⅱ型神经元的免疫组织化学特征。
Cell Tissue Res. 2010 May;340(2):257-65. doi: 10.1007/s00441-010-0954-z. Epub 2010 Mar 26.
6
Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine.腔内苦味剂的分泌作用以及苦味受体T2Rs在人和大鼠大肠中的表达。
Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G971-81. doi: 10.1152/ajpgi.90514.2008. Epub 2009 Jan 29.
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What is "physiological" intestinal inflammation and how does it differ from "pathological" inflammation?什么是“生理性”肠道炎症，它与“病理性”炎症有何不同？
Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S77-8. doi: 10.1002/ibd.20618.
8
Fibre-free diet leads to impairment of neuronally mediated muscle contractile response in rat distal colon.无纤维饮食导致大鼠远端结肠神经元介导的肌肉收缩反应受损。
Neurogastroenterol Motil. 2006 Dec;18(12):1093-101. doi: 10.1111/j.1365-2982.2006.00847.x.
9
Prostaglandin E2 receptor distribution and function in the gastrointestinal tract.前列腺素E2受体在胃肠道中的分布与功能
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10
Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors.通过脂质介质及其同源核G蛋白偶联受体的自分泌信号传导：基于前列腺素E2、血小板活化因子和溶血磷脂酸1受体的范例
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前列腺素E2在结肠运动中的作用：前列腺素E2可引发并增强大鼠结肠纵行平滑肌的自发收缩。

Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon.

作者信息

Iizuka Yumiko, Kuwahara Atsukazu, Karaki Shin-Ichiro

机构信息

Laboratory of Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences/Institute for Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.

出版信息

J Physiol Sci. 2014 Mar;64(2):85-96. doi: 10.1007/s12576-013-0295-2. Epub 2013 Oct 30.

DOI:10.1007/s12576-013-0295-2
PMID:24170253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10717406/
Abstract

The aim of this study was to determine which PGE2 receptors (EP1-4 receptors) influence colonic motility. Mucosa-free longitudinal smooth muscle strips of the rat middle colon spontaneously induced frequent phasic contractions (giant contractions, GCs) in vitro, and the GCs were almost completely abolished by a cyclooxygenase inhibitor, piroxicam, and by an EP3 receptor antagonist, ONO-AE3-240, but enhanced by tetrodotoxin (TTX). In the presence of piroxicam, exogenous PGE2, both ONO-AE-248 (EP3 agonist), and ONO-DI-004 (EP1 agonist) induced GC-like contractions, and increased the frequency and amplitude. These effects of EP receptor agonists were insensitive to TTX and ω-conotoxins. In immunohistochemistry, the EP1 and EP3 receptors were expressed in the longitudinal smooth muscle cells. These results suggest that the endogenous PGE2 spontaneously generates and enhances the frequent phasic contractions directly activating the EP1 and EP3 receptors expressed on longitudinal smooth muscle cells in the rat middle colon.

摘要

本研究的目的是确定哪些前列腺素E2受体（EP1 - 4受体）影响结肠运动。大鼠中结肠无黏膜的纵行平滑肌条在体外可自发诱导频繁的相性收缩（巨收缩，GCs），环氧化酶抑制剂吡罗昔康和EP3受体拮抗剂ONO - AE3 - 240几乎完全消除了GCs，但河豚毒素（TTX）可增强GCs。在吡罗昔康存在的情况下，外源性前列腺素E2、ONO - AE - 248（EP3激动剂）和ONO - DI - 004（EP1激动剂）均可诱导类似GC的收缩，并增加频率和幅度。EP受体激动剂的这些作用对TTX和ω - 芋螺毒素不敏感。在免疫组织化学中，EP1和EP3受体在纵行平滑肌细胞中表达。这些结果表明，内源性前列腺素E2通过直接激活大鼠中结肠纵行平滑肌细胞上表达的EP1和EP3受体，自发产生并增强频繁的相性收缩。