Wirén Sara, Häggström Christel, Ulmer Hanno, Manjer Jonas, Bjørge Tone, Nagel Gabriele, Johansen Dorthe, Hallmans Göran, Engeland Anders, Concin Hans, Jonsson Håkan, Selmer Randi, Tretli Steinar, Stocks Tanja, Stattin Pär
Department of Surgery and Perioperative Sciences, Urology and Andrology, Umeå University, 901 87, Umeå, Sweden,
Cancer Causes Control. 2014 Feb;25(2):151-9. doi: 10.1007/s10552-013-0317-7. Epub 2013 Oct 31.
To assess the association between height and risk of cancer and cancer death.
The metabolic syndrome and cancer project is a prospective pooled cohort study of 585,928 participants from seven cohorts in Austria, Norway, and Sweden. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for cancer incidence and death were estimated in height categories and per 5-cm increment for each cancer site using Cox proportional hazards model.
During a mean follow-up of 12.7 years (SD = 7.2), 38,862 participants were diagnosed with cancer and 13,547 participants died of cancer. Increased height (per 5-cm increment) was associated with an increased overall cancer risk in women, HR 1.07 (95 % CI 1.06-1.09), and in men, HR 1.04 (95 % CI 1.03-1.06). The highest HR was seen for malignant melanoma in women, HR 1.17 (95 % CI 1.11-1.24), and in men HR 1.12 (95 % CI 1.08-1.19). Height was also associated with increased risk of cancer death in women, HR 1.03 (95 % CI 1.01-1.16), and in men, HR 1.03 (95 % CI 1.01-1.05). The highest HR was observed for breast cancer death in postmenopausal women (>60 years), HR 1.10 (95 % CI 1.00-1.21), and death from renal cell carcinoma in men, HR 1.18 (95 % CI 1.07-1.30). All these associations were independent of body mass index.
Height was associated with risk of cancer and cancer death indicating that factors related to height such as hormonal and genetic factors stimulate both cancer development and progression.
评估身高与癌症风险及癌症死亡之间的关联。
代谢综合征与癌症项目是一项对来自奥地利、挪威和瑞典七个队列的585,928名参与者进行的前瞻性汇总队列研究。使用Cox比例风险模型，按身高类别以及每个癌症部位每增加5厘米，估计癌症发病率和死亡率的风险比（HRs）及95%置信区间（CIs）。
在平均12.7年（标准差=7.2）的随访期间，38,862名参与者被诊断患有癌症，13,547名参与者死于癌症。身高增加（每增加5厘米）与女性总体癌症风险增加相关，HR为1.07（95%CI 1.06 - 1.09），男性为HR 1.04（95%CI 1.03 - 1.）。女性中恶性黑色素瘤的HR最高，为1.17（95%CI 1.11 - 1.24），男性为HR 1.12（95%CI 1.08 - 1.19）。身高还与女性癌症死亡风险增加相关，HR为1.03（95%CI 1.01 - 1.16），男性为HR 1.03（95%CI 1.01 - 1.05）。绝经后女性（>60岁）乳腺癌死亡的HR最高，为1.10（95%CI 1.00 - 1.21），男性肾细胞癌死亡的HR为1.18（95%CI 1.07 - 1.30）。所有这些关联均独立于体重指数。
身高与癌症风险及癌症死亡相关，表明与身高相关的因素，如激素和遗传因素，会刺激癌症的发生和发展。
