Department of Endocrinology, Aalborg University Hospital, Hobrovej 18-22, DK-9000 Aalborg, Denmark.
Eur J Endocrinol. 2014 Feb 1;170(2):K5-9. doi: 10.1530/EJE-13-0622. Print 2014 Feb.
Neuroendocrine tumours are most frequently located in the gastrointestinal organ system or in the lungs, but they may occasionally be found in other organs.
We describe a 56-year-old woman suffering from a carcinoid syndrome caused by a large serotonin-secreting pituitary tumour. She had suffered for years from episodes of palpitations, dyspnoea and flushing. Cardiac disease had been suspected, which delayed the diagnosis, until blood tests revealed elevated serotonin and chromogranin A in plasma. The somatostatin receptor (SSR) scintigraphy showed a single-positive focus in the region of the pituitary gland and MRI showed a corresponding intra- and suprasellar heterogeneous mass. After pre-treatment with octreotide leading to symptomatic improvement, the patient underwent trans-cranial surgery with removal of the tumour. This led to a clinical improvement and to a normalisation of SSR scintigraphy, as well as serotonin and chromogranin A levels.
To our knowledge, this is the first reported case of a serotonin-secreting tumour with a primary location in the pituitary.
神经内分泌肿瘤最常位于胃肠道器官系统或肺部，但偶尔也可能出现在其他器官中。
我们描述了一例 56 岁女性因大的分泌 5-羟色胺的垂体肿瘤引起类癌综合征。她多年来一直有心悸、呼吸困难和潮红发作。曾怀疑有心脏疾病，这导致了诊断的延误，直到血液检查显示血浆中血清素和嗜铬粒蛋白 A 升高。生长抑素受体 (SSR) 闪烁显像显示在垂体区域有一个单一阳性焦点，MRI 显示相应的鞍内和鞍上异质性肿块。在奥曲肽预处理导致症状改善后，患者接受了经颅手术切除肿瘤。这导致了临床改善以及 SSR 闪烁显像、血清素和嗜铬粒蛋白 A 水平的正常化。
据我们所知，这是首例报告的位于垂体的分泌 5-羟色胺的肿瘤。
