Schött U, Sjöstrand U, Thorén T, Berséus O
Acta Anaesthesiol Scand. 1985 Nov;29(8):767-74. doi: 10.1111/j.1399-6576.1985.tb02298.x.
Microaggregate-poor erythrocyte concentrate with 3% dextran-60 as a plasma substitute was compared with microaggregate-poor whole blood for replacement of intra-operative and immediately postoperative blood loss. Sixty patients undergoing total hip arthroplasty randomly received either of these two forms of therapy. In accordance with the clinical routine of our orthopedic department, an infusion of 500 ml of 6% dextran-70 (Macrodex) was given as thrombo-prophylaxis in both groups. Use of 3% dextran-60 as a plasma substitute in blood component therapy for surgical hemorrhage of up to 50% of the calculated blood volume caused no increase in bleeding tendency or frequency of postoperative hematoma compared with whole blood replacement. Plasma protein levels were low immediately postoperatively in patients given the dextran, but from the 4th postoperative day onward there was no difference between the groups. Applied in clinical practice, this would be efficient in saving plasma for other urgent purposes.
将含有3%右旋糖酐-60作为血浆代用品的少微粒红细胞浓缩液与少微粒全血用于术中及术后即刻失血的替代治疗进行比较。60例行全髋关节置换术的患者随机接受这两种治疗方式中的一种。按照我们骨科临床常规，两组均给予500ml 6%右旋糖酐-70（Macrodex）进行血栓预防。在手术失血达计算血容量的50%的情况下，与全血替代相比，使用3%右旋糖酐-60作为血浆代用品进行血液成分治疗并未增加出血倾向或术后血肿发生率。给予右旋糖酐的患者术后即刻血浆蛋白水平较低，但术后第4天起两组之间无差异。在临床实践中应用，这将有效地节省血浆用于其他紧急用途。
