Ha Tae-Sun
Tae-Sun Ha, Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju 361-240, South Korea.
World J Nephrol. 2013 Feb 6;2(1):1-10. doi: 10.5527/wjn.v2.i1.1.
Podocytes covering the glomerular basement membrane over the glomerular capillary consist of three morphologically and functionally different segments, the cell body, major processes and extending finger-like foot processes (FPs). The FPs of neighboring podocytes are connected by a continuous adherent junction structure named the slit diaphragm (SD). The extracellular SD is linked to the intracellular, a highly dynamic, cytoskeleton through adaptor proteins. These adaptor proteins, such as CD2-associated protein, zonula occludens 1, β-catenin, Nck and p130Cas, located at the intracellular SD insertion area near lipid rafts, have important structural and functional roles. Adaptor proteins in podocytes play important roles as a structural component of the podocyte structure, linking the SD to the cytoskeletal structure and as a signaling platform sending signals from the SD to the actin cytoskeleton. This review discusses the roles of adaptor proteins in the podocyte cytoskeletal structure and signaling from the SD to the actin cytoskeleton.
覆盖在肾小球毛细血管上的肾小球基底膜的足细胞由三个形态和功能不同的部分组成，即细胞体、主要突起和延伸的指状足突（FPs）。相邻足细胞的足突通过一种名为裂孔隔膜（SD）的连续黏附连接结构相连。细胞外的SD通过衔接蛋白与细胞内高度动态的细胞骨架相连。这些衔接蛋白，如CD2相关蛋白、紧密连接蛋白1、β-连环蛋白、Nck和p130Cas，位于脂质筏附近的细胞内SD插入区域，具有重要的结构和功能作用。足细胞中的衔接蛋白作为足细胞结构的结构成分发挥重要作用，将SD与细胞骨架结构相连，并作为一个信号平台将信号从SD传递到肌动蛋白细胞骨架。本综述讨论了衔接蛋白在足细胞细胞骨架结构中的作用以及从SD到肌动蛋白细胞骨架的信号传导。
