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迷走神经刺激对耐药性癫痫中海马神经元的神经保护作用。

Neuroprotective effects of vagus nerve stimulation on hippocampal neurons in intractable epilepsy.

机构信息

Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China.

出版信息

Med Hypotheses. 2013 Dec;81(6):1066-8. doi: 10.1016/j.mehy.2013.10.005. Epub 2013 Oct 16.

DOI:10.1016/j.mehy.2013.10.005
PMID:24176140
Abstract

Vagus nerve stimulation (VNS) and electroacupuncture (EA) at specific acupoints have both shown promising anticonvulsant effects in intractable epilepsy patients. The differences between these therapies are target selection and stimulation parameter modulation. It has been demonstrated that EA of the extremities results in stimulation of the VN and protection of hippocampus neurons, possibly by an anti-inflammatory response. Similarly, VNS can also suppress neural inflammatory responses, implying that VNS may protect hippocampal neurons against seizure-induced damage.

摘要

迷走神经刺激(VNS)和特定穴位电针(EA)在难治性癫痫患者中均显示出有希望的抗惊厥作用。这些疗法的区别在于目标选择和刺激参数调节。已经证明,四肢的 EA 会刺激 VN 并保护海马体神经元,可能通过抗炎反应。同样,VNS 也可以抑制神经炎症反应,这表明 VNS 可能防止海马体神经元免受癫痫发作引起的损伤。

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