Owen F, Chambers D R, Cooper S J, Crow T J, Johnson J A, Lofthouse R, Poulter M
Brain Res. 1986 Jan 1;362(1):185-8. doi: 10.1016/0006-8993(86)91415-0.
Serotonergic mechanisms have been investigated in postmortem brain samples from controls and suicide victims. The concentrations of 5-hydroxytryptamine (serotonin; 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were determined in occipital cortex and hippocampus and the high-affinity binding of ligands to the 5-HT1, 5-HT2 and imipramine-binding sites was assessed in frontal cortex, occipital cortex and hippocampus. The only significant difference between the two groups was a modest increase in 5-HIAA levels in the hippocampus of suicide victims. There was no evidence to suggest that those suicide victims with a clinical history of depression represented a subgroup with altered metabolite levels or binding values. The storage conditions of the samples were not related to the metabolite levels or binding values. There was, however, a significant positive correlation between [3H]imipramine binding and age in some brain regions. The results do not provide any evidence of gross alterations in 5-HT mechanisms in suicide or depression.
已在对照组和自杀受害者的尸检脑样本中研究了血清素能机制。测定了枕叶皮质和海马体中5-羟色胺（血清素；5-HT）和5-羟吲哚乙酸（5-HIAA）的浓度，并评估了额叶皮质、枕叶皮质和海马体中配体与5-HT1、5-HT2及丙咪嗪结合位点的高亲和力结合情况。两组之间唯一显著的差异是自杀受害者海马体中5-HIAA水平略有升高。没有证据表明那些有抑郁症临床病史的自杀受害者代表代谢物水平或结合值发生改变的亚组。样本的储存条件与代谢物水平或结合值无关。然而，在某些脑区，[3H]丙咪嗪结合与年龄之间存在显著正相关。结果未提供任何证据表明自杀或抑郁症中5-HT机制存在明显改变。
