简单一锅法区域选择性碳水化合物 6-O-磷酸化和海藻糖不对称拆分。
Simple one-pot regioselective 6-O-phosphorylation of carbohydrates and trehalose desymmetrization.
机构信息
Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
出版信息
Chem Commun (Camb). 2013 Dec 21;49(98):11497-9. doi: 10.1039/c3cc47180b.
PMID:24177789
Abstract
Biologically essential carbohydrate 6-phosphates, especially trehalose 6-phosphate, can be synthesized easily in excellent overall yields in 2 steps involving minimum protecting group manipulations. We can cleave the diphenylphosphate group for further synthetic objectives.
摘要
生物必需的碳水化合物 6-磷酸酯，特别是海藻糖 6-磷酸酯，可以很容易地通过两步合成，总收率非常好，仅涉及最小的保护基操作。我们可以裂解二苯膦酸酯基团以实现进一步的合成目标。
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