环孢素 A 中 MeBmt 氨基酸侧链 C-C 键的异常断裂。
An unusual side chain C-C cleavage at the MeBmt amino acid in cyclosporin A.
机构信息
Galena Co., Research Unit, Branišovská 31, CZ-370 05, České Budějovice, Czech Republic.
出版信息
Amino Acids. 1996 Jun;10(2):145-51. doi: 10.1007/BF00806587.
The mixture of products obtained by alkaline treatment of cyclosporin A was analyzed by HPLC-continuous-flow-FAB/MS. The changes involve the atypical amino acid (4R)-4-((E)-2-butenyl)-4,N-dimethyl-L-threonine (MeBmt) without affecting the cyclic structure. The main degradation pathway is dehydration producing all four possible anhydro-MeBmt containing cyclosporins. A new cyclosporin, [Sar(1)]CS, resulting from the side chain cleavage of MeBmt has been isolated and characterized.
用 HPLC-连续流动-FAB/MS 分析环孢菌素 A 经碱性处理得到的产物混合物。这些变化涉及非典型氨基酸 (4R)-4-((E)-2-丁烯基)-4，N-二甲基-L-苏氨酸 (MeBmt)，但不影响环结构。主要的降解途径是脱水生成所有四种可能的含有脱水-MeBmt 的环孢菌素。从 MeBmt 的侧链裂解得到的一种新的环孢菌素 [Sar(1)]CS 已被分离和表征。
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