Bonatti V, Rolli A, Botti G
Eur Heart J. 1985 Nov;6 Suppl D:131-43. doi: 10.1093/eurheartj/6.suppl_d.131.
In 58 human subjects monophasic action potentials (MAPs) were recorded with suction electrodes in several areas of the right ventricle (RV). Individual differences between the longest and the shortest RV MAP durations indicate that: normally (40 subjects) ventricular repolarization is almost synchronous; QT prolongation due either to bradycardia or to amiodarone treatment (eight cases) may be the result of a uniform lengthening of ventricular repolarization, when ventricular arrhythmias are not present; in long QT syndromes (LQTSs) of differing etiology (10 cases), in which severe ventricular arrhythmias are present, marked individual differences in RV MAP duration are present and correspond with pathological asynchrony of ventricular repolarization. Also observed in the LQTSs are morphological alterations (humps) in the terminal phase of the longest MAPs. Humps, interpreted as pathological delayed repolarization phenomena, may lead to focal re-excitation which seems to play a key role in the genesis of the arrhythmias complicating LQTSs.
在58名人类受试者中，使用吸引导电极记录了右心室（RV）多个区域的单相动作电位（MAPs）。最长和最短RV MAP持续时间之间的个体差异表明：正常情况下（40名受试者）心室复极几乎是同步的；当不存在室性心律失常时，由心动过缓或胺碘酮治疗引起的QT延长（8例）可能是心室复极均匀延长的结果；在不同病因的长QT综合征（LQTSs，10例）中，存在严重室性心律失常，RV MAP持续时间存在明显个体差异，且与心室复极的病理性不同步相对应。在LQTSs中还观察到最长MAPs终末阶段的形态学改变（驼峰）。驼峰被解释为病理性延迟复极现象，可能导致局灶性再兴奋，这似乎在LQTSs并发心律失常的发生中起关键作用。
