Collett J H, Rees J A
J Pharm Pharmacol. 1975 Sep;27(9):647-52. doi: 10.1111/j.2042-7158.1975.tb09526.x.
Dissolution rates of salicylic acid from a constant surface area into a series of aqueous micellar polysorbate 20 solutions at pH 1-0 to 4-0 have been measured using two different methods; a stirred beaker and a rotating disc technique. The micellar molecular weight of polysorbate 20 has been obtained from light scattering and differential refractometry data and used with other independently determined physical data to calculate diffusion coefficients of the diffusing species. Linear multiple regression analysis was used to assess the dependence of drug dissolution rate on the diffusion coefficient and the viscosity of the dissolution medium.
采用两种不同方法，即搅拌烧杯法和旋转圆盘法，测定了水杨酸在pH值为1.0至4.0的一系列水性聚山梨醇酯20胶束溶液中，从恒定表面积的溶解速率。聚山梨醇酯20的胶束分子量已从光散射和示差折射数据中获得，并与其他独立测定的物理数据一起用于计算扩散物种的扩散系数。使用线性多元回归分析来评估药物溶解速率对扩散系数和溶解介质粘度的依赖性。
