Krasna I H, Howell C, Vega A, Ziegler M, Koop C E
J Pediatr Surg. 1986 Jan;21(1):26-9. doi: 10.1016/s0022-3468(86)80645-5.
A mouse model for the study of necrotizing enterocolitis is presented. It is a model of temporary intestinal ischemia and consists of occluding both superior mesenteric vessels with a bulldog clamp for varying periods of time. The resultant lesions resemble the intestinal lesions seen in necrotizing enterocolitis in respect to the gradual development of the necrotizing lesions and their patchy distribution. We also studied the effect of intravenous saline and low molecular weight dextran in preventing the development of these ischemic lesions. In moderate ischemia, saline and dextran show a similar protective effect, and in severe ischemia, both show a protective effect, with dextran being more effective than saline.
本文介绍了一种用于研究坏死性小肠结肠炎的小鼠模型。它是一种暂时性肠道缺血模型，通过用动脉夹夹闭肠系膜上动静脉不同时间来构建。所形成的病变在坏死性病变的逐渐发展及其散在分布方面与坏死性小肠结肠炎中所见的肠道病变相似。我们还研究了静脉输注生理盐水和低分子右旋糖酐对预防这些缺血性病变发生的作用。在中度缺血时，生理盐水和右旋糖酐显示出相似的保护作用，而在重度缺血时，二者均显示出保护作用，且右旋糖酐比生理盐水更有效。
