Chien Y W, Akers M J, Yonan P K
J Pharm Sci. 1975 Oct;64(10):1632-5. doi: 10.1002/jps.2600641008.
The extent of plasma binding, the partition coefficient, and the pKb of 13 disopyramide derivatives were determined. The structural variation on the diisopropylaminoethyl group of disopyramide molecules influenced these physical parameters to varying degrees. Results demonstrated that the extent of interaction between drugs and human plasma was a linear function of their lipophilicity and inversely proportional to the magnitude of the pKb value.
测定了13种双异丙吡胺衍生物的血浆结合程度、分配系数和pKb。双异丙吡胺分子二异丙基氨基乙基上的结构变化对这些物理参数有不同程度的影响。结果表明，药物与人血浆之间的相互作用程度是其亲脂性的线性函数，且与pKb值大小成反比。
