Vincent S H, Holeman B, Cully B C, Muller-Eberhard U
Life Sci. 1986 Jan 27;38(4):365-72. doi: 10.1016/0024-3205(86)90084-6.
Three types of hepatic proteins, a heme-binding Z protein, a mixture of the glutathione S-transferases and a cytochrome P450 isozyme, were shown to be susceptible to photodynamic cross-linking and loss in antigenicity by naturally occurring porphyrins. At 50 microM, uroporphyrin caused the most and protoporphyrin the least photodecomposition. Hemopexin, a specific serum heme carrier, was photodecomposed but no cross-linking was detected. Heme and scavengers of singlet oxygen partially prevented protein photodecomposition.
三种肝脏蛋白，一种血红素结合Z蛋白、谷胱甘肽S-转移酶混合物和一种细胞色素P450同工酶，被证明易受天然存在的卟啉的光动力交联作用并丧失抗原性。在50微摩尔浓度下，尿卟啉引起的光分解最多，原卟啉最少。血红素结合蛋白，一种特定的血清血红素载体，发生了光分解，但未检测到交联。血红素和单线态氧清除剂部分地防止了蛋白质光分解。
