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致敏性食物残留参考剂量的建立:VITAL 专家小组报告。

Establishment of Reference Doses for residues of allergenic foods: report of the VITAL Expert Panel.

机构信息

Food Allergy Research & Resource Program, University of Nebraska, Lincoln, NE, USA.

Food Allergy Research & Resource Program, University of Nebraska, Lincoln, NE, USA.

出版信息

Food Chem Toxicol. 2014 Jan;63:9-17. doi: 10.1016/j.fct.2013.10.032. Epub 2013 Oct 30.

Abstract

In 2011, an expert panel was assembled to establish appropriate Reference Doses for allergenic food residues as a part of the VITAL (Voluntary Incidental Trace Allergen Labeling) program of The Allergen Bureau of Australia & New Zealand (ABA). These Reference Doses would guide advisory labeling decisions for use on food labels. Individual NOAELs and LOAELs were obtained from clinical challenges of food-allergic subjects. Statistical dose-distribution models (log-normal, log-logistic, Weibull) were applied to the individual NOAELs and LOAELs for each allergenic food. The Reference Doses, in terms of mg of total protein from the allergenic food, were based upon either the ED01 (for peanut, cow's milk), the 95% lower confidence interval of the ED05 (for wheat, soybean, cashew, shrimp, sesame seed, mustard, and lupine), or both (egg, hazelnut) using all appropriate statistical dose-distribution models. Reference Doses were established for 11 allergenic foods ranging from 0.03 mg for egg protein to 10mg for shrimp protein. Reference Doses were not established for fish or celery due to poor model fits with existing data. Reference Doses were not established for other tree nuts beyond hazelnut and cashew because of the absence of data on NOAELs and LOAELs from individual subjects.

摘要

2011 年,一个专家小组被召集起来,作为澳大利亚和新西兰过敏原局(ABA)自愿偶然微量过敏原标签(VITAL)计划的一部分,为过敏原食物残留制定适当的参考剂量。这些参考剂量将指导食品标签上的咨询标签决策。个体无观察到不良反应水平(NOAEL)和最低观察到不良反应水平(LOAEL)是从食物过敏人群的临床挑战中获得的。统计剂量分布模型(对数正态、对数逻辑、威布尔)应用于每种过敏原食物的个体 NOAEL 和 LOAEL。参考剂量以过敏原食物的总蛋白毫克数表示,基于 ED01(花生、牛奶)、ED05 的 95%置信区间下限(小麦、大豆、腰果、虾、芝麻、芥末和羽扇豆)或两者(鸡蛋、榛子),使用所有适当的统计剂量分布模型。为 11 种过敏原食物制定了参考剂量,范围从 0.03 毫克鸡蛋蛋白到 10 毫克虾蛋白。由于现有数据的模型拟合不佳,未为鱼类或芹菜制定参考剂量。由于个体的 NOAEL 和 LOAEL 数据缺失,除榛子和腰果以外的其他坚果类的参考剂量也未建立。

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