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影响择期腰椎后路手术后住院时间的因素:一项多因素分析

Factors affecting length of stay after elective posterior lumbar spine surgery: a multivariate analysis.

作者信息

Gruskay Jordan A, Fu Michael, Bohl Daniel D, Webb Matthew L, Grauer Jonathan N

机构信息

Department of Orthopedics and Rehabilitation, Yale University School of Medicine, 800 Howard Ave., New Haven, CT 06510, USA.

Department of Orthopedics and Rehabilitation, Yale University School of Medicine, 800 Howard Ave., New Haven, CT 06510, USA.

出版信息

Spine J. 2015 Jun 1;15(6):1188-95. doi: 10.1016/j.spinee.2013.10.022. Epub 2013 Nov 1.

Abstract

BACKGROUND CONTEXT

Elective posterior lumbar fusion is a common surgical procedure, but reported length of hospital stay is variable (usually 3-7 days). The effect of a limited number of factors on length of stay (LOS) has previously been evaluated. However, multivariate analysis using LOS as a dependent variable to separate potentially confounding variables has not been performed.

PURPOSE

To facilitate setting of realistic expectations and considering the significant costs of hospitalization, it would be ideal to have a clear understanding of the variables affecting LOS for this surgery.

STUDY DESIGN/SETTING: This is a retrospective case series at a tertiary care center.

PATIENT SAMPLE

One hundred three patients undergoing elective, open, one- to three-level posterior lumbar instrumented fusion (with or without decompression) by the orthopedic spine service at our institution between January 2010 and June 2012 were included in the study.

OUTCOME MEASURES

LOS was determined from the date of surgery to the date of discharge.

METHODS

Preoperative factors (patient demographics, previous surgery, levels instrumented, American Society of Anesthesiologists [ASA] score, and major medical comorbidities including diabetes, hypertension, malignancy, pulmonary disease, or heart disease), intraoperative factors (complications, drain placement, estimated blood loss, blood transfusion, fluids administered, operating room time, and surgery time), and postoperative factors (drain removal, blood transfusion, complications, and discharge destination) were collected and analyzed with multivariate stepwise regression to determine predictors of LOS. "Postoperative complications" were excluded as an independent variable from the regression analysis because of its close relationship with LOS. No funding was received for the completion of this study, and there are no potential conflicts of interests.

RESULTS

Our sample included 70 one-level, 26 two-level, and 7 three-level operations. Average LOS was 3.6±1.8 days (mean±SD) with the range 0 to 12 days. Of this cohort, 79% (81 of 103) had a stay of 4 days or less. The only preoperative variables associated with LOS in the multivariate model were age (p=.038) and ASA score (p=.001). History of heart disease (p=.005) was significantly associated with a decreased hospital stay. Intraoperative complications included six dural tears and one pedicle fracture. No intraoperative factors were found to be associated with a longer LOS. Postoperative complications occurred in 32% of patients (33 of 103). Common complications included anemia requiring transfusion (11), altered mental status (8), pneumonia (4), hardware complications requiring reoperation (3). Only one serious complication, renal failure, occurred. Average LOS for patients with a postoperative complication was 5.1±2.3 vs. 2.9±0.9 days for patients with no complication (p<.001). Discharge to a subacute or nursing facility (p<.001) was significantly associated with increased LOS. Levels fused were not predictive of LOS, possibly due to the skew toward one-level cases in our sample.

CONCLUSION

Patients who are older and have widespread systemic disease tend to stay in the hospital longer after surgery. Contrary to our expectations, no single comorbidity was predictive of longer hospital stays. Heart disease was associated with a shorter LOS, but this may have been due to a more extensive preoperative workup and closer medical management. Intraoperative events did not affect LOS; however, postoperative events did. These data should prove useful for counseling patients and setting expectations of patients and the health care team.

摘要

背景

选择性腰椎后路融合术是一种常见的外科手术,但报告的住院时间各不相同(通常为3 - 7天)。此前已评估了少数因素对住院时间的影响。然而,尚未进行以住院时间作为因变量来区分潜在混杂变量的多变量分析。

目的

为便于设定现实的预期并考虑到住院的巨大成本,若能清楚了解影响该手术住院时间的变量将是理想的。

研究设计/地点:这是一项在三级医疗中心进行的回顾性病例系列研究。

患者样本

纳入了2010年1月至2012年6月间在我们机构接受骨科脊柱服务进行选择性、开放性、一至三级腰椎后路器械融合术(有或无减压)的103例患者。

观察指标

住院时间从手术日期至出院日期确定。

方法

收集术前因素(患者人口统计学资料、既往手术史、融合节段、美国麻醉医师协会[ASA]评分以及包括糖尿病、高血压、恶性肿瘤、肺部疾病或心脏病在内的主要内科合并症)、术中因素(并发症、引流管放置、估计失血量、输血、补液量、手术室时间和手术时间)以及术后因素(引流管拔除、输血、并发症和出院去向),并通过多变量逐步回归分析来确定住院时间的预测因素。由于“术后并发症”与住院时间密切相关,故在回归分析中作为自变量被排除。本研究的完成未获得任何资金支持,且不存在潜在利益冲突。

结果

我们的样本包括70例单节段、26例双节段和7例三节段手术。平均住院时间为3.6±1.8天(均值±标准差),范围为0至12天。在该队列中,79%(103例中的81例)住院时间为4天或更短。多变量模型中与住院时间相关的唯一术前变量是年龄(p = 0.038)和ASA评分(p = 0.001)。心脏病史(p = 0.005)与住院时间缩短显著相关。术中并发症包括6例硬脊膜撕裂和1例椎弓根骨折。未发现术中因素与更长的住院时间相关。32%的患者(103例中的33例)发生了术后并发症。常见并发症包括需要输血的贫血(11例)、精神状态改变(8例)、肺炎(4例)、需要再次手术的内固定并发症(3例)。仅发生了1例严重并发症,即肾衰竭。有术后并发症患者的平均住院时间为5.1±2.3天,而无并发症患者为2.9±0.9天(p < 0.001)。出院至亚急性或护理机构(p < 0.001)与住院时间延长显著相关。融合节段不能预测住院时间,可能是由于我们样本中偏向单节段病例。

结论

年龄较大且患有广泛全身性疾病的患者术后往往住院时间更长。与我们预期相反,没有单一合并症可预测更长的住院时间。心脏病与较短的住院时间相关,但这可能是由于术前更广泛的检查和更密切的医疗管理。术中事件不影响住院时间;然而,术后事件会影响。这些数据应有助于为患者提供咨询并设定患者及医疗团队的预期。

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