Numao Y, Suga H, Iriuchijima J
Jpn Heart J. 1975 Nov;16(6):719-30. doi: 10.1536/ihj.16.719.
Cardiac output of unanesthetized spontaneously hypertensive rats (SHR) and normotensive control rats (NCR) was measured by an aortic pressure pulse contour method. A catheter was introduced into the aortic arch under ether anesthesia and aortic pressure curves were recorded after the recovery from anesthesia. Stroke volume was calculated by reading required pressure and time data on the tracings and substituting them into a special equation. Cardiac output per min per body weight was not significantly different between SHR and NCR. Arterial pressure and total peripheral resistance were higher in SHR than in NCR. On ganglion blockade with hexamethonium bromide in the conscious state, arterial pressure decreased more markedly in SHR than in NCR. Though arterial pressure was still significantly (P less than 0.05) higher in SHR after blockade, cardiac output was larger in SHR more than to account for the difference in arterial pressure. Total peripheral resistance was lower in SHR than in NCR after blockade. It is concluded that, even in the conscious state as in the anesthetized state, the major contribution to the hypertensive state in SHR is an increase in total peripheral resistance due to an elevation of the sympathetic tone.
采用主动脉压力脉搏轮廓法测量未麻醉的自发性高血压大鼠（SHR）和正常血压对照大鼠（NCR）的心输出量。在乙醚麻醉下将导管插入主动脉弓，麻醉恢复后记录主动脉压力曲线。通过读取描记图上所需的压力和时间数据并将其代入一个特殊方程来计算每搏输出量。SHR和NCR之间每千克体重每分钟的心输出量无显著差异。SHR的动脉血压和总外周阻力高于NCR。在清醒状态下用溴化六甲铵进行神经节阻滞时，SHR的动脉血压下降比NCR更明显。尽管阻滞后SHR的动脉血压仍显著（P<0.05）高于正常，但SHR的心输出量增加幅度超过了动脉血压差异所能解释的范围。阻滞后SHR的总外周阻力低于NCR。结论是，即使在清醒状态下如同在麻醉状态一样，SHR高血压状态的主要原因是交感神经张力升高导致总外周阻力增加。
