Versavel C, Lebreton de Vonne T, Mouray H
Br J Exp Pathol. 1986 Feb;67(1):65-72.
During trypsin perfusions in normal rabbits and in rabbits in acute phase reaction (APR), there is no modification in cardiorespiratory functions except in the instant preceding death. The fibrinogen level decreases and fibrin is deposited in the vascular lumen. The alpha 2 macroglobulin (alpha 2 M) content diminishes more rapidly than the alpha I macroglobulin (alpha I M) content; moreover, in subjects in APR, the decrease of alpha I M is further slowed with increasing perfusion rates, whereas the decrease in alpha 2 M remains constant. All the alpha M are completely combined at death. Therefore, it can be assumed that only the hepatic filtering of the alpha I M enzyme complex is subject to saturation.
在正常兔和处于急性期反应（APR）的兔中进行胰蛋白酶灌注时，除了濒死瞬间外，心肺功能没有改变。纤维蛋白原水平降低，纤维蛋白沉积在血管腔内。α2巨球蛋白（α2M）含量比α1巨球蛋白（α1M）含量下降得更快；此外，在处于APR的实验对象中，随着灌注速率的增加，α1M的下降进一步减缓，而α2M的下降保持恒定。所有的αM在死亡时完全结合。因此，可以假定只有α1M酶复合物的肝脏滤过会饱和。
