Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, Yunnan 650091, PR China; Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, Yunnan 650091, PR China.
Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, Yunnan 650091, PR China; Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, Yunnan 650091, PR China.
Biotechnol Adv. 2014 Mar-Apr;32(2):290-5. doi: 10.1016/j.biotechadv.2013.10.010. Epub 2013 Nov 2.
Olfaction in Caenorhabditis elegans is a versatile and sensitive strategy to seek food and avoid danger by sensing volatile chemicals emitted by the targets. The ability to sense attractive odor is mainly accomplished by the AWA and AWC neurons. Previous studies have shown the components of the olfaction signal pathway in these two amphid chemosensory neurons, but integration of the individual signaling components requires further elucidation. Here we review the progresses in our understanding of signal pathways for attractive olfaction involving AWA and AWC neurons, and discuss how the different signal molecules might employ the common molecular cascades to transduce the olfactory system and guide behavior in each neuron.
秀丽隐杆线虫的嗅觉是一种通过感知目标物释放的挥发性化学物质来寻找食物和避免危险的多功能且敏感的策略。感知有吸引力气味的能力主要是通过 AWA 和 AWC 神经元来实现的。先前的研究已经显示了这两个触角化学感觉神经元中嗅觉信号通路的组成部分，但单个信号成分的整合需要进一步阐明。在这里，我们回顾了我们对涉及 AWA 和 AWC 神经元的吸引性嗅觉信号通路的理解进展，并讨论了不同的信号分子如何利用共同的分子级联来转导嗅觉系统并指导每个神经元的行为。
