Sawamura A, Sperelakis N, Azuma J
Eur J Pharmacol. 1986 Jan 21;120(2):235-9. doi: 10.1016/0014-2999(86)90546-7.
The effect of taurine on cardiac slow action potentials (APs) during hypoxic superfusion was studied in isolated guinea-pig papillary muscles. Ca2+-dependent slow APs were induced by isoproterenol (10(-6) M) in preparations which were voltage-inactivated by high (25 mM) K+. Although taurine had no effect on the slow AP parameters during normoxia, taurine (10 mM) superfusion significantly protected against the decline of slow APs produced by hypoxia. Taurine also restored slow APs that had been previously abolished by hypoxia. Therefore, taurine exposure may protect the Ca2+ slow channels which are inhibited or blocked by hypoxic conditions.
在离体豚鼠乳头肌中研究了牛磺酸对缺氧灌流期间心脏慢动作电位（APs）的影响。在高钾（25 mM）使电压失活的标本中，异丙肾上腺素（10(-6) M）诱导产生依赖Ca2+的慢动作电位。尽管在常氧期间牛磺酸对慢动作电位参数没有影响，但牛磺酸（10 mM）灌流可显著保护缺氧产生的慢动作电位下降。牛磺酸还可恢复先前因缺氧而消失的慢动作电位。因此，牛磺酸暴露可能保护被缺氧条件抑制或阻断的Ca2+慢通道。
